Description of the medicine: Nalidixic acid (Acidum nalidixicum)

NALIDIX ACID (Acidum nalidixicum). 1-Ethyl-7-methyl-4-one-1, 8-naphthyridine-3-carboxylic acid.

Synonyms: Nevigramon, Negrum (The firm name "Negra" from the word "gram-negative"), Cistidix, Nagram, Nalidin, Nalidixanum, Nalidixic acid, Nalidixin, Naligram, Nalix, Nalurin, Naxuril, Negram, Nevigramon, Nogram, Notricel, Specifin, Urodixin , Urogram, Uroneg, Wintomylon, and others.

Crystalline powder of light yellow color. Insoluble in water.

It is a synthetic antibacterial drug. Effective in infections caused by gram-negative bacteria, intestinal, dysentery and typhoid bacillus, proteus, stick Klebsiella (Friedlander). Bacteriostatic and bactericidal. Effective against strains resistant to antibiotics and sulfonamides. It is very ineffective against gram-positive cocci (staphylococcus, streptococcus, pneumococcus) and pathogenic anaerobes.

The drug is well absorbed from the gastrointestinal tract. About 80% is excreted in the urine unchanged. The half-life is approximately 8 hours, but with renal insufficiency reaches 20 hours or more.

Applied mainly with infections of the urinary tract (cystitis, pyelitis, pyelonephritis) caused by microorganisms sensitive to the drug; Most effective in acute infections. Assign also for the prevention of infections in kidney and bladder operations. It is recommended for enterocolitis, cholecystitis, inflammation of the middle ear and other diseases caused by microorganisms sensitive to the preparation, including those resistant to other antibacterial agents.

Adults take inside 0.5 g (1 capsule or 1 tablet), and for more serious infections - 1 g 4 times a day. The course of treatment is not less than 7 days. With long-term treatment, apply 0.5 g 4 times a day.

Children are prescribed at the rate of 60 mg / kg, distributing the daily dose into 4 equal parts.

Nalidixic acid is usually well tolerated; However, nausea, vomiting, diarrhea, headache, dizziness are possible. There may be allergic reactions (dermatitis, fever, eosinophilia), as well as increase the sensitivity of the skin to sunlight (photodermatosis).

In patients with impaired cerebral circulation, parkinsonism, epilepsy, convulsions may appear. In connection with the possibility of convulsive reactions, you should beware of drug overdose in children. Pronounced adverse reactions require a temporary or complete discontinuation of the drug.

Contraindications of liver function, oppression of the respiratory center. Greater caution is necessary in the case of insufficient kidney function. You can not prescribe women in the first 3 months of pregnancy and children under 2 years.

Do not use the drug simultaneously with nitrofurans, as this reduces the antibacterial effect.

Forms of release: in capsules or tablets of 0.5 g.

Storage: List B.