Description medications: Fenamin (Phenaminum)

Fenaminom (Phenaminum). d, l-1-phenyl-2-aminopropane sulfate or d, l- b -fenilizopropilamina sulfate.

Synonyms: Aktedrin, Alentol, Amphamine, Amphedrine , Amphethamini sulfas, Amphetamine sulfate, Benzedrine sulfate, Benzpropamin, Euphodyn, Isoamin; Ortedrine, Psychedrinum, Psychoton, Racephen, Raphetamin, Sympamin, Sympatedrine and others.

The white crystalline powder bitter taste. Soluble in water (1:20 in cold 1: 3 hot), slightly soluble in alcohol.

Amphetamine is a synthetic compound derived fenilalkilamina. On chemical structure and pharmacological properties, some (mainly on the effect on the peripheral parts of the sympathetic nervous system), it is close to the preparations of the adrenaline.

According to the structure different from the lack of noradrenaline and adrenaline hydroxyls in the aromatic ring and aliphatic chain, which gives it greater resistance and, moreover, allows to easily overcome the blood-brain barrier; branched chain aliphatic character (the presence of the methyl group in a - position to the amino group) protects it from oxidative deamination molecule monoamine oxidase.

Due to resistance in the body the effects of amphetamine are durable and appear when taking it inside.

Fenamin is a potent stimulator of the central nervous system. The stimulatory effect of the drug is largely due to its effect on the part of the brain stem.

The neurochemical mechanism of action plays an important role amphetamine its ability to cause the release of granules presynaptic nerve terminals, and dopamine and norepinephrine stimulated, thus the central noradrenergic and dopaminergic receptors more. It also has a slight inhibitory effect on monoamine oxidase activity and inhibits reverse neuronal uptake of dopamine and norepinephrine.

Fenamin also has peripheral adrenergic activity (it stimulates the a - and b - adrenergic receptors); it causes peripheral vasoconstriction, increased heart rate, increased blood pressure, relaxation of muscles of the bronchi, dilated pupils. These effects are more persistent, but less pronounced than that of adrenaline.

When properly dosed amphetamine, strengthening the processes of excitation in the central nervous system, reduces the feeling of fatigue, has a general stimulating effect, results in an improved mood, sense of tidal forces, vitality, improving efficiency, reducing the need for sleep.

Amphetamine and its analogs weaken and shorten sleep caused by drugs and narcotics, in connection with which they are called sometimes awaken amines.

The drug has anoreksigennoy activity, ie, It reduces appetite and contributes to a more rapid onset of a sense of food saturation.

Amphetamine long time was considered one of the main psychoactive agents.