Description of the drug: Florimycin sulfate (Florimycini sulfas)

FLORIMYCINA SULFATE (Florimycini sulfas).

Florimycin is an antibiotic that is a product of the life activity of fragrant fungi Streptomyces floridae or other related organisms.

Synonyms: Viomycin, Florimycinum sulfuricum, Geliomycin, Vinactane, Viocin, Viomycinum sulfuricum, Vionactan.

Powder or porous mass of white or almost white color, odorless, slightly bitter in taste. Easily soluble in water.

By chemotherapeutic properties is close to kanamycin (see). Has a specific bacteriostatic effect on the mycobacterium tuberculosis; Is also active against gram-positive and gram-negative bacteria.

It is a "reserve" drug in the treatment of various forms and localizations of tuberculosis. He is prescribed to patients with tuberculostatic drugs of the first series who proved ineffective due to the development of resistance to them or for other reasons, as well as with intolerance to other antituberculous drugs.

Apply intramuscularly (in the intestine it is not absorbed). Enter (slowly) deep into the upper outer quadrant of the buttocks. Injectable solutions are prepared before use; In a vial containing 0.5-1.0 g (500,000-1,000,000 units) of the drug, Z is injected with 5 ml of sterile water for injection, isotonic sodium chloride solution or 0.25-0.5% solution of novocaine. The solution should be used within the first 24 hours.

The daily intake for adults is 1 g.

Enter daily for 0.5 g 2 times a day (morning and evening) or 1 g 1 time per day - for 6 consecutive days, on the 7th day break. With prolonged treatment, sometimes break for 2 days a week (in a row or 2 to 3 days for one day).

The highest single dose for adults 1 g, daily 2 g. The dose for patients with a body weight below 50 kg and people over 60 years is 0.5 0.75 g per day.

In children, florimycin sulfate should be used with caution (because of the difficulty in assessing the effect of the drug on hearing). Assign it to children suffering from chronic destructive tuberculosis, with ineffectiveness of other means.

The daily dose for children is 0.015-0.02 g (15-20 mg / kg) (not more than 0.5 g for children and 0.75 g for adolescents).

It should be borne in mind that florimycin can have a toxic effect on the auditory nerve, so treatment should be controlled by audiometry. At the first signs of hearing loss, the drug is canceled.

Florimycin can be combined with preparations of I and II series (PASK, cycloserin, etc.). However, it can not be combined with streptomycin and other antibiotics showing ototoxic effect (neomycin, monomycin, kanamycin, etc.).

When using florimycin, headache, allergic dermatitis, and protein in the urine may appear.

It should be borne in mind that in patients with impaired renal excretory function, excretion of florimycin from the body is delayed, which may lead to an increase in its toxic effect.

Weakening of neurotoxic and allergic reactions can be facilitated by the use of calcium pantothenate (see).

Contraindications: defeat of the VIII pair of cranial nerves and impaired renal function.