Description of the medicine: Vinblastine (Vinblastinum)

VINBLASTINUM.

The alkaloid contained in the plant is periwinkle pink (Vinca rosea L.), and also in the catarrhtus rose plant (Catharanthus roseus L.).

It is produced in the form of sulphate.

Refers to the alkaloids of the indole series.

Synonyms: Velbe, Cytoblastin, Blastovin, Cytoblastine, Exal, Periblastine, Velban, Velbe, Vinblastine, Vincaleukoblastine.

The national name "Rosevine" (Rosevinum).

White or white with a creamy shade of fine crystalline powder. Hygroscopic, sensitive to light. Easily soluble in water, almost insoluble in alcohol.

Vinblastine is a cytostatic substance with antitumor activity.

The mechanism of the antitumor effect is explained by the ability of the drug to block the mitosis of cells at the metaphase stage.

Vinblastine acts depressingly on leukopoiesis and thrombocytopoiesis; Does not significantly affect erythropoiesis.

Apply vibplastin (rozevin) with lymphogranulomatosis, hematosarcoma, myeloma, choriocarcinoma.

Enter the drug intravenously once a week. Before use, dissolve the contents of the vial (5 mg) in 5 ml of isotonic sodium chloride solution. The initial dose is 0.025 mg / kg, then the dose is gradually increased (follow the number of leukocytes and platelets in the blood) to 0.15-0.3 mg / kg. The course dose of 100 - 120 mg. In the absence of effect, the drug is stopped at a total dose of 50 mg. If a therapeutic effect is observed, prolonged maintenance therapy is performed, selecting a dose that, if used regularly, does not reduce the level of white blood cells in the blood below 3 x 10 9 / l. The drug is administered 1 time in 2 - 4 weeks. In the case of deterioration of the patient, the intervals between administrations are reduced.

Vinblastine (rozevin) is widely used in complex chemotherapy of tumors in combination with other antitumor drugs.

When applying the drug, general weakness, loss of appetite, nausea, vomiting, abdominal pain, paresthesia, albuminuria, jaundice, stomatitis, urticaria, depression, alopecia, phlebitis are possible.

The treatment is carried out under the systematic control of blood patterns; Analyzes are carried out once in 3 days. With a decrease in the number of leukocytes to 3 x 10 9 / l and platelets to 100 x 10 9 / l, the drug is stopped. If necessary, a transfusion of blood or its elements is prescribed, antibiotics.

The drug is contraindicated in the oppression of the hematopoietic system, acute gastrointestinal diseases and peptic ulcer of the stomach and duodenum, in the terminal stage of the disease.

It should beware of getting solutions under the skin due to severe tissue irritation.

Form release: in lyophilized form (porous mass of white or white with a slightly yellowish hue) in ampoules and vials of 0.005 g (5 mg).

Storage: List A. In the dark place at a temperature of not more than +10 C.