Description of the medicine: Cyproterone acetate
Cyproterone. 6-Chloro-1b, 2b-dihydro-17-hydroxy-3'H-cyclo-propa [1,2, pregna-1, 4, 6-triene-3, 20-dione acetate.
Synonyms: Androkur, Androcur, Cyprostat, Cyproteronacetat.
Ciproterone acetate is an antiandrogen of the steroid structure. Oppressing the formation of a complex of dihydrotestosterone with androgen receptors in target cells, including in the nuclei of prostate cancer cells. Oppresses also the release of gonadotropins and thus delays the action of endogenous testosterone on tumor cells.
Apply cyproterone acetate for inoperable prostate cancer. Sometimes it is effective in tumor resistance to other hormonal drugs.
Sometimes cyproteronacetate is used in women with severe manifestations of hyperandrogenic activity (severe hirsutism, severe androgen-dependent alopecia, severe forms of acne and seborrhea), as well as in premature sexual development in children.
Is taken orally in the form of tablets after eating, squeezed with liquid.
The usual initial dose for men is 1 tablet (50 mg) 2 times a day. If necessary, increase the dose to 2 tablets 2 to 3 times a day. After the onset of the therapeutic effect, reduce the dose to 1 - 0.5 tablets per day.
Women are usually prescribed 1 tablet (50 mg) 2 times a day.
Children are given 0.5-1 tablets 2 times a day.
At men at application of a preparation development of a gynecomastia, morbidity in the field of mammary glands is possible. Women may oppress ovulation.
When using large doses, there may be abnormalities in liver function, fluid retention in the body.
In pregnancy, the use of cyproterone acetate is contraindicated.
It should be taken into account that cyproterone acetate is characterized by a weak androgenic activity, which causes caution regarding the risk of its use in prostate cancer. In connection with this, recently, non-steroidal anti-androgens have been preferred.
Form release: tablets of 0.05 g (50 mg) in a package of 50 pieces.