Description of the medicine: Aminoglutethimide (Aminoglutethimide)
Aminoglutethimide (Aminoglutethimide). 3-Ethyl-3- (p-aminophenyl) -2,6-dioxopiperidine.
Synonyms: Mammoth, Orimeten, Sutadren, Elipten, Mamomit, Orimeten.
On the chemical structure, aminoglutethimide is similar to the hypnotics and anticonvulsant drug glutetimide (synonyms: Noxiron-Nohuron, Doriden-Doriden). It differs only in the presence of an amino group in the phenyl nucleus.
Aminoglutethimide also has anticonvulsant activity, but it attracted the greatest interest as an inhibitor of adrenocorticosteroid synthesis, primarily hydrocortisone. It also inhibits the biosynthesis of estrogens.
Aminoglutetimide is used in Isenko-Cushing syndrome and for "pharmacological adrenalectomy" in tumors of the adrenal cortex (see Chloditan). Applied also for breast cancer.
Assign inside by 0.25 g 2 - 4 times a day. Take daily for a long time (depending on the course of the disease).
The drug is usually well tolerated. Sometimes there are allergic skin reactions, angioedema.
Product: tablets of 0.25 g.