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Description medications: clorazepate (Clorazepate)

Clorazepate (Clorazepate).

The complex compound of the potassium salt of 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepinkarbonovoy acid with potassium hydroxide.

Synonyms: Apo-clorazepate, Trunks, Apo-Chlorazepate, Tranxen.

Light yellow powder, soluble in water, insoluble in organic solvents.

Strong anxiolytic (antifobicheskoy) activity, and little pronounced muscle relaxant, hypnotic and sedative effects.

It refers to the so-called "day" tranquilizers.

When ingestion absorbed quickly and almost completely, with max of 45-60 minutes, T1 / 2 - 2 days; biotransformation in the liver with the formation nordiazepama, excreted by the kidneys.

Apply with anxiety, irritability, with partial seizures, as well as for the prevention of delirium in chronic alcoholism.

Assign into adults and 0.015-0.03 g (15-30 mg) per day (0.005-0.01 g per reception), may increase the dose to 0.06 g (60 mg) per day, in acute alcohol intoxication the first day to 0.09 g (90 mg) per day. Elderly or debilitated patients assigned to night 0.00375 (3.75 mg), children - 0.5 mg / kg in divided doses.

Possible side effects: drowsiness, memory impairment, ataxia, diplopia, paradoxical reactions such as aggressiveness and irritability, indigestion, hypotension, decreased hematocrit and others.

The drug is contraindicated in respiratory failure and children up to 9 years.

Muscle relaxants, barbiturates, antipsychotics, means for anesthesia and alcohol increase (each) clorazepate effects.

Specific antagonist is flumazenil (cm.).

Product form: capsules of 0.00375; 0.005 and 0.01 g (3.75, 5 and 10 mg).