Description of the medicine: Flupentixol (Flupentixol)

Flupentixol.

4- [3- [2- (Trifluoromethyl) -9H-thioxanthen-9-ylidene] propyl] -1-piperazineethanol.

Synonym: Fluansoxol, Fluancsol.

Has antipsychotic, anxiolytic, antidepressant and moderate sedative effect.

It is a blocker of central dopamine receptors.

After oral administration is well absorbed, Cmax is 3-6 h; T S - 35 h (for decanoate - 3 weeks); Undergoes biotransformation in the liver, is excreted as metabolites mainly through the intestine and partly by the kidneys.

Applied: in large doses for psychoses with a predominance of hallucinations, delusions, thinking disorders and in small - with depression, chronic neurotic disorders and psychosomatic disorders, accompanied by anxiety, asthenia and apathy.

Assign inside. For psychoses, the initial daily dose of 0.005-0.015 g (5-15 mg) in 2-3 doses (up to 0.04 g per day), supporting - 0,005-0,02 g (5-20 mg) once a day - in the morning ; At border conditions - 0.001 g (1 mg) 1 time per day, if necessary, the daily dose is increased to 0.002-0.003 g (2-3 mg).

When the drug is used, extrapyramidal disorders often arise, insomnia or drowsiness may arise, malignant neuroleptic syndrome, and violation of liver tests.

The drug is contraindicated with excitation and hyperactivity.

With caution appoint with convulsive syndrome, chronic hepatitis and cardiovascular diseases.

Strengthens the effect of alcohol, barbiturates and other drugs that depress the central nervous system, reduces - levodopa.

Method of production: tablets (pills) of 0.0005 and 0.001 g (0.5 and 1 mg) (N.50) and 0.005 g (5 mg) of flupentixol hydrochloride (N.100); 10% solution (drops) of flupentixol dihydrochloride in 10 ml vials.

There is also a drug of prolonged action of flupenthixola decanoate. Assign intramuscularly at 0,05-0,2 g (50-200 mg) 1 time every 2-4 weeks, after relief of acute symptoms, the dose is reduced to 0.02-0.2 g (20-200 g).

Form release: 2% and 10% oily solutions for intramuscular injection in ampoules of 1 ml, 2% - in ampoules of 2 ml and bottles of 10 ml and 10% - in bottles of 5 ml.

Storage: List B.