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Medication Description: Flupentixol (Flupentixol)

FLUENTENTIXOL (Flupentixol).

4- [3- [2- (Trifluoromethyl) -9H-thioxanthen-9-ylidene] propyl] -1-piperazine ethanol.

Synonym: Fluanksol, Fluancsol.

It has antipsychotic, anxiolytic, antidepressant and mild sedative effects.

It is a central dopamine receptor blocker.

After ingestion is well absorbed, Cmax is 3-6 hours; T Ѕ - 35 hours (for decanoate - 3 weeks); undergoes biotransformation in the liver, is excreted in the form of metabolites mainly through the intestines and partially by the kidneys.

Apply: in large doses with psychosis with a predominance of hallucinations, delusions, thinking disorders and in small - with depression, chronic neurotic disorders and psychosomatic disorders, accompanied by anxiety, asthenia and apathy.

Assign inside. In psychoses, the initial daily dose of 0.005-0.015 g (5-15 mg) in 2-3 doses (up to 0.04 g per day), supporting - 0.005-0.02 g (5-20 mg) once a day - in the morning ; in borderline conditions - 0.001 g (1 mg) 1 time per day, if necessary, increase the daily dose to 0.002-0.003 g (2-3 mg).

When using the drug, extrapyramidal disorders often occur, insomnia or drowsiness may occur, neuroleptic malignant syndrome, hepatic impairment.

The drug is contraindicated in the excitation and hyperactivity.

Be wary appointed with convulsive syndrome, chronic hepatitis and cardiovascular diseases.

Strengthens the effect of alcohol, barbiturates and other drugs that depress the central nervous system, reduces - levodopa.

Method of production: tablets (dragee), 0.0005 and 0.001 g (0.5 and 1 mg) (N.50) and 0.005 g (5 mg) of flupentixol hydrochloride (N.100); 10% solution (drop) of flupentixol dihydrochloride in 10 ml vials.

There is also a drug of prolonged action flupentixol decanoate. Prescribed intramuscularly at 0.05-0.2 g (50-200 mg) 1 time every 2-4 weeks, after the relief of acute symptoms, reduce the dose to 0.02-0.2 g (20-200 g).

Product form: 2% and 10% oil solutions for intramuscular administration in 1 ml ampoules, 2% in 2 ml ampoules and 10 ml bottles and 10% in 5 ml bottles.

Storage: List B.