Description of the medicine: Hinapril (Quinapril)
Ethyl 2- [N- [1-carboxy-3-phenylpropyl] -alanyl] -1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride.
Synonyms: Accupro, Quinapril, Accupro.
White or off-white amorphous powder. Soluble in water.
Alanine-containing ACE inhibitor (does not have sulfhydryl groups).
Gastrointestinal tract absorbs about 40% of the dose, C max is 1 h, T S - 3 h; Is excreted unchanged in urine and bile.
Applied with arterial hypertension and congestive heart failure.
There is a positive experience with the use of quinapril in the acute period of myocardial infarction (there was a decrease in the number of patients with signs of heart failure, the frequency and degree of progression of left ventricular dilation, an increase in the ejection fraction, etc.).
In arterial hypertension, the initial dose of 0.01 g (10 mg) 1 time per day (when combined with diuretics and with renal dysfunction 2.5 mg per day). If necessary, the dose is gradually increased to 0.02-0.04 g (20-40 mg) per day (in 1-2 doses). The maximum daily dose of 0.08 g (80 mg).
There is evidence that for antihypertensive efficacy, hanipril is superior to lisinopril, enalapril and hydrochlorothiazide and is not inferior to atenol.
With congestive heart failure, the initial dose of 0.0025 g (2.5 mg), supporting - 0.01-0.02 g (in 1-2 doses), the maximum - 0.04 g (40 mg) per day.
Possible side effects and contraindications are basically the same as in enalapril and captopril.
Forms of release: tablets of 0.005; 0.01 and 0.02 g (5, 10 and 20 mg) (N. 10, 30, 50).
Storage: List B.