Description medications: atorvastatin (Atorvastarin)
The calcium salt of (βR, δR) -2- (p-fluorophenyl) -β, δ-dihydroxy-5-isopropyl-3-phenyl-4- (phenylcarbamoyl) pyrrolo-1-heptanoate.
Synonym: Lipitor, Liprimar.
New (1990s.) Synthetic HMG-CoA reductase inhibitors, considered as the second-generation statin.
On chemical structure differs from the "classic" statin lovastatin and has similarities with fluvastatin (includes fluorophenyl radical, and the residue geptanoevoy acid).
Atorvastatin features action over other statins is increased a greater reduction in LDL cholesterol and triglycerides in the serum, which is associated with a longer inhibition of HMG-CoA reductase (20-30 h).
In the digestive tract rapidly absorbed, bioavailability (relative) amounts to 95-99%, C max - 1-2 h, T ½ - 14 hours; derived bile.
Due to the specific action of the drug used as monotherapy in atherosclerotic dyslipidemia not only in isolated cases of hypercholesterolemia, hyperlipidemia and the combined (including hypertriglyceridemia), as well as coronary heart disease with elevated levels of total cholesterol or LDL cholesterol.
Applied inside (regardless of the meal). The starting dose of 0.01 g (10 mg), 1 time per day. Determined every 4 weeks and blood lipid composition, depending on the results clarify dose. The maximum daily dose - 0.08 g (80 mg). The effect is within 2 weeks and reaches a maximum of 4 weeks.
As with other lipid-lowering drugs, atorvastatin is used in the background of the non-drug interventions (diet therapy, etc) aimed at lowering cholesterol.
The drug is generally well tolerated; may, however, dyspepsia, headache, insomnia, fatigue, myalgia, angioneurotic edema, paresthesia, peripheral neuropathy.
Contraindicated in acute liver diseases, pregnancy and breastfeeding.
Product: pills to 0.01; 0.02, and 0.04 g (N. 10, 30).