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Description of the medicine: Acarbose (Acarbose)


Synonym: Glucobay, Glucobay.

The oligosaccharide, which is an inhibitor of pancreatic α-amylase and intestinal α-glucosidase. It inhibits the cleavage of oligo-, tri- and disaccharides to glucose and other monosaccharides and slows the absorption of glucose in the small intestine, thus preventing the development of postprandial (post-meal) hyperglycemia.

It is absorbed in part (35% of the dose), C max is 1 h, T S - 2 h; Undergoes biotransformation in the gastrointestinal tract (intestinal bacteria and digestive enzymes), is excreted mainly with feces.

They are used as an adjuvant (if the diet is observed) in the treatment of non-insulin dependent diabetes mellitus. With insulin-dependent diabetes mellitus is not indicated.

Assign inside at the beginning of food intake (without chewing) or before meals, starting with 0.05 g, gradually increasing the dose to 0.2 g 3 times a day.

The drug is usually well tolerated. Possible flatulence, diarrhea.

Contraindications: diabetic ketoacidosis, cirrhosis of the liver, inflammatory bowel disease, severe renal dysfunction, pregnancy, breast-feeding.

Form release: tablets of 0.05 and 0.1 g (50 and 100 mg) (N. 15, 30).