Description medications: Alendronate sodium (Alendronat sodium)
Alendronate sodium (Alendronat sodium).
The sodium salt of (4-amino-1-hydroxybutylidene) -difosfonovoy acid.
Synonym: Fosamax, Fosamax.
The white crystalline powder. Soluble in water, slightly soluble in alcohol.
It has the ability to bind hydroxyapatite contained in the bones and inhibit the activity of osteoclasts, bone resorption exercising.
When administered drug accumulates in large amounts in bone tissue.
The ingestion absorbed about 25% of the dose, bioavailability is only 0.6-0.8%, S T - 10 h.
Applied for the treatment of osteoporosis, especially in women during menopause, as well as in Paget's disease (osteitis deformans).
Is the inside of 0.01 g (10 mg) 1 times a day for half an hour before eating (or earlier). Drink a glass of the ordinary, not mineral water. Extras appointed interior calcium supplements at the rate of 0.5 grams of calcium per day. Treatment for a long time (years). After 3 years, the dose of alendronate sodium (Fosamax) is reduced to 0.005 g (5 mg) per day.
Paget's disease of 0.04 g administered daily for 6 months.
During the treatment there is an increase in bone mineral density and reduce the frequency of new fractures.
In applying the drug may be disorders of the gastrointestinal tract (constipation or diarrhea, flatulence, pain in the stomach, esophagitis), allergic reactions (skin rash, erythema), headache.
Contraindications hypocalcemia, severe renal insufficiency.
Calcium and products containing it should be taken no earlier than 1-2 hours after administration of alendronate, as delays absorption of Alendronate (and other bisphosphonates) from the intestine.
Product: pills to 0.01 g (10 mg) (28 N. The).