Description of the medicine: Acitretin (Acitretin)
9- (4-Methoxy-2,3,6-trimethylphenyl) -3,7-dimethyl-2,4,6,8-nonatetraenoic acid.
Synonym: Neotigazon, Neotigason.
According to the chemical structure, acitretin (neotigazone) differs from tigazone in that it is a tigazone corresponding to an acid, and tigazone is its ethyl ester (i.e., contains a COO 2 H 5 radical in the side chain instead of a COOH radical).
The action of acitretin is close to tigazone, but it is somewhat better tolerated, although it has some side effects, as well as teratogenic activity.
Quickly and completely absorbed in the digestive tract, bioavailability is 60%, C max -1-4 h, T S - 50 h; Undergoes biotransformation in the liver (in some cases, etretinate is formed), is excreted in the urine and bile for 1 month to 2 years.
Applied with severe forms of psoriasis, congenital ichthyosis, lichen (red, hairy, flat, frigid), Darya's disease.
The effect of the drug is related to the ability to normalize the processes of renewal, differentiation and keratinization of skin cells.
Assign inside (at meal time): adults on 0.025-0.03 g (25-30 mg) once a day, after 2-4 weeks, an increase in the daily dose to 0.075 g (75 mg) is possible; Children - 0.5 mg / kg per day (if necessary up to 1 mg / kg per day, but not more than 35 mg per day).
When applying the drug, hypervitaminosis A (dry skin and mucous membranes, skin peeling, brittle nails, hair loss, hyperlipidemia, hypercalcemia, etc.) are likely.
Contraindicated in pregnancy (the risk of teratogenic action), with severe violations of the liver and kidneys, severe cardiovascular diseases.
Do not use the drug together with retinol (vitamin A), tetracycline antibiotics, methotrexate, other drugs that disrupt liver and kidney function.
Form release: capsules of 0.01 and 0.025 g (10 and 25 mg) (N. 50, 100).