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Description medications: sargramostim (Sargramostim)
Sargramostim (Sargramostim).
Synonyms: Leikin, Prokin, Leukine, Prokine.
Glycosylated polypeptide consisting of 127 amino acid residues. The molecular weight of 15 500-19 500 Da. (C 639 H 1002 N 168 O 198 S 8).
Get a genetically engineered via the yeast Saccharomyces cerevisiae.
It stimulates the formation of granulocytes, eosinophils and makrofogav.
Administered intravenously (infusion - 2 hours), or subcutaneously.
Doses set individually.
Typically used (neutropenia associated with chemotherapy, cytostatic malignancies and bone marrow transplants) from the calculation of 250 micrograms per 1 m 2 of body surface per day. If necessary, increase the dose to 500 mg / m 2 per day.
In applying the drug may be a violation of vascular permeability, fluid retention, shortness of breath, weakness, fever, thrombophlebitis, thrombosis.
Product: powder for injection solutions in bottles of 0.25 and 0.5 mg.
The contents of the vial are dissolved in 1 ml of sterile water for injection (not vstryahivaya- avoid foam formation). Infusion then diluted in 0.9% sodium chloride solution.
Storage: at a temperature of from +2 to +8 ° C.
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