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Description of the medicine: Ethidronate sodium (Etidronate sodium)

SODIUM ETIDRONATE (Etidronate sodium).

Disodium salt of (1-hydroxyethylidene) diphosphonic acid.

Synonyms: Xidiphon, Pleistat, Didronel, Pleostat, Xydifonum.

When ingestion is well absorbed, T составляет is about 6 hours; Not exposed to biotransformation, excreted by the kidneys.

Indications for use are basically the same as in other bisphosphonates (osteoporosis, Paget's disease, hypercalcemia in cancer diseases, etc.). They are also used in the oxalate type of kidney stone disease.

Assign inside and intravenously.

Usual dose for adults inside (fasting) 5-7 (to 20) mg / kg per day in combination with calcium preparations (0.5-1 g) and vitamin D (400-800 ED of cholecalciferol or 0.5-1 μg alfacalcidol ) Courses for 1-2 months.

Intravenous drip slowly (2 h) at a dose of 7.5 mg / kg (in 250 ml of 0.9% sodium chloride solution) for 3-5 days.

Possible side effects: metallic taste in the mouth, a sense of touch, a violation of kidney function.

The drug is contraindicated in hypocalcemia, impaired renal function and pregnancy.

Forms of release: tablets of 0.4 g (N. 14); 20% concentrate for oral solution in vials of 50, 100 and 250 ml; 5% solution for infusion.