Description of the medicine: Ethidronate sodium (Etidronate sodium)
SODIUM ETHIDRONATE (Etidronate sodium).
Disodium salt of (1-hydroxyethylidene) diphosphonic acid.
Synonyms: Xidiphon, Pleostat, Didronel, Pleostat, Xydifonum.
When ingested, it is well absorbed, T Ѕ is about 6 hours; not subjected to biotransformation, excreted by the kidneys.
Indications for use are basically the same as for other bisphosphonates (osteoporosis, Paget's disease, hypercalcemia in cancer, etc.). They are also used for the oxalate type of kidney stone disease.
Assign inside and intravenously.
The usual dose for adults inside (on an empty stomach) is 5-7 (up to 20) mg / kg per day in combination with calcium (0.5-1 g) and vitamin D (400-800 IU cholecalciferol or 0.5-1 μg alfacalcidol ) courses of 1-2 months.
Intravenous drip is administered slowly (2 hours) at a dose of 7.5 mg / kg (in 250 ml of 0.9% sodium chloride solution) for 3-5 days.
Possible side effects: metallic taste in the mouth, disturbances of touch, impaired renal function.
The drug is contraindicated in hypocalcemia, impaired renal function and pregnancy.
Method of release: tablets of 0.4 g (N. 14); 20% concentrate for oral solution in 50, 100 and 250 ml vials; 5% solution for infusion.