Description of the medicine: Acetylsalicylic acid (Acidum acetylsalicylicum)
ACETYLSALICYLIC ACID (Acidum acetylsalicylicum).
Synonyms: Anopyrin, Apo-Asa, Aspivatrin, Aspilate, Aspinate, Aspirin, Aspirin-direct, Aspirin-Cardio, Aspirin, Asca, Aspirin, ACC-Ratiofarm, Acentherin, Acetylsalicilbene, Acilpyrin, ACC, Bartel Drags ASK, Bufferan, Bufferin, Colfarith, Mycristin, Our choice is an analgesic, Novandol, Novasan, Novasen, New Aspar, Nju-sylz 75 cardio-aspirin, Plolid, Ronal, Salorin, Sprite-Lime, Trombo ACC, Walsh-Asalgin, Upsarin , He-El-Payne, Elcapin, Acenterin, Acesal, Acetosal, Acetylin, Acetylsalicylbene, Acetylsalicylic Acid, Acetysal, Acylpyrin, Anopyrin, Apo-Asa, Aspilite, Aspirin, Aspisol, Aspivatrin, Asposal, Aspro, Astrin, Ataspin, Bartell drugs ASA, Bayaspirin, Bebaspin, Benaspir, Bispirine, Bufferan, Bufferin, Caprin, Cetasal, Citopyrine, Clariprin, Colfarit, Darosal, Durasal, Easprin, Elkapin, Endosalil, Endospirin, Eutosal, Genasprine, Helicon, HL-Paim, Isopirin, Istopirin, Micristin, Monasalyl, New-asper, Novandol, Novasan, Novasen, Novosprin, NU-seals 75 cardio-aspirin, Our choice - analgetic, Panspiril, Plidol, Polopiryna, Prodol, Rhonal, Rodopytin, Ronal, Ruspirm, Salacetin, Saletin, Salorin , Sprit-Lime, Temperal, Trombo ASS, Vicapirine, Walsh-asalgin, Zorprin, and others.
White small needle crystals or light crystalline powder. It is slightly soluble in water (soluble in hot water), easily - in alcohol, in solutions of caustic and carbonic acid.
Acetylsalicylic acid has an anti-inflammatory, antipyretic, and analgesic effect, and it is widely used in febrile states, the head of pain, migraine 2 , neuralgia and as an antirheumatic agent.
The anti-inflammatory effect of acetylsalicylic acid (and other sadicilates) is explained by its effect on the processes taking place in the inflammatory focus: a decrease in the permeability of capillaries, a decrease in the activity of hyaluronidase, a restriction of the energy supply of the inflammatory process by inhibiting the formation of ATP, etc. In the mechanism of anti-inflammatory action, inhibition of biosynthesis Prostaglandins.
Antipyretic effect is associated with the effect on the hypothalamic centers of thermoregulation.
The analgesic effect is due to the influence on the centers of pain sensitivity and the ability of salicylates to reduce the algogenic effect of bradykinin.
An important feature of acetylsalicylic acid, which has recently been given great importance, is the ability to exert an antiaggregatory effect (to inhibit spontaneous and induced platelet aggregation).
Substances that have anti-aggregation effects have become widely used in medicine to correct hemorheological disorders and prevent thrombotic complications in patients with myocardial infarction, cerebrovascular disorders and other cardiovascular diseases. In this regard, it is appropriate to identify these substances in the group of antiaggregational agents. These properties of acetylsalicylic acid are considered in the corresponding section (see Antiaggregants).
Acetylsalicylic acid stimulates the excretion of uric acid as a result of a violation of its reabsorption in the tubules of the kidneys.