Description of the medicine: Vancomycin (Vancomycin)

Vancomycin.

Synonyms: Vancolide, Vancocin, Vanmixan, Edicyin, Edicin, Vancocin, Vancoled, Vanmixan.

Powder. It is readily soluble in water, moderately in methanol.

Tricyclic glycopeptide antibiotic produced by Amycolatopsis orientalis.

It is active against a number of gram-positive microorganisms (staphylococci, streptococci, pneumococci, enterococci, corynebacteria, listeria, actinomycetes and clostridia).

Forming a complex with acyl-D-alanine-D-alanine mucoprotein of the bacterial cell wall, it disrupts its formation, permeability of the cytoplasmic membrane and synthesis of RNA, which leads to bacterial lysis.

When ingestion is not absorbed; After intravenous administration, therapeutic concentrations in the blood are maintained for 8-10 hours, T составляет is 1-8 hours, rapidly penetrates into the pleural cavity and myocardium, synovial and ascitic fluids; Is excreted mainly by the kidneys in an unchanged form.

Applied with especially severe infectious and inflammatory diseases caused mainly by golden (methicillin-resistant) and coagulase-negative staphylococci, enterococci and pneumococci, insensitive to penicillins, cephalosporins and other antibiotics: sepsis, endocarditis, pneumonia, lung abscess, osteomyelitis, meningitis, peritonitis, skin infections , Pseudomembranous colitis (inside, with ineffectiveness of metronidazole); For the prevention of postoperative infections (mainly in cardiovascular surgery and orthopedics), and also (inside) for acute and chronic liver diseases (including hepatic encephalopathy).

Assign intravenously and inside.

Intravenously, drip (for at least 1 hour) an adult of 2 g (in 200 ml of a 5% solution of glucose or an isotonic solution of sodium chloride) per day in 2-4 doses (in surgical practice - 1 g for 1 h before the operation); Children - 40-60 mg / kg (up to 2 g) per day in 4 divided doses.

Inside (in the form of a solution) with pseudomembranous colitis, adults are prescribed 0.5-2 g per day, children - 40 mg / kg per day (3-4 sessions); With hepatic encephalopathy - 1-2 g 3 times a day for 5-7 days.

Possible side effects: dyspeptic phenomena, allergic reactions, in rare cases, oto- and nephrotoxic effect; After intravenous administration - thrombophlebitis, vasculitis, fever, neutropenia, thrombocytopenia, with rapid (intravenous) administration - arterial hypotension, burning sensation, reddening of the upper body, pain and muscle spasms in the back and chest area.

Contraindications: neuritis of the auditory nerve, renal failure, I trimester of pregnancy.

Form release: lyophilized powder in vials of 0.5 and 1 g.

Storage: List B.