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Description medications: methoxyflurane (Methoxyfluranum)

Methoxyflurane (Methoxyfluranum) 1, 1 - (Difluoro-2, 2-dichloro-1 methoxyethane)

Synonyms: Ingalan, Pentran, Inhalanum, Methofluranum, Metofane, Penthrane , Pentran.

Colorless transparent volatile liquid with a specific smell of fruit. The density of 1.42. The boiling point of 105 C. At room temperature, and the concentrations used for anesthesia, does not explode and is not flammable.

Methoxyflurane is a powerful narcotic drug, more active than halothane and ether. Turning off the consciousness and surgical anesthesia occur at a concentration of 1.5-2% vol., And is required to maintain anesthesia 0.5-0.8 vol. % In the inspired mixture. Anesthesia begins, however slowly, is expressed in a stage of excitation; awakening after the cessation of feeding the mixture occurs in 15 - 60 min anesthetic depression completely passes through a 2 - 3 hours.

Due to the slow onset of effect and duration of excitation stage methoxyflurane used primarily not for self-anesthesia, and in combination with nitrous oxide, barbiturates, muscle relaxants. Usually begins with induction of anesthesia barbiturate, then apply the mixture to maintain anesthesia containing 0.5 - 1 vol. % Methoxyflurane combined with nitrous oxide and oxygen (1: 1).

Anesthesia methoxyflurane may be carried out through an open, semi-open, semi-closed system, but the most safe use of the machine with a special evaporator located outside the circulation system.

Methoxyflurane is prolonged analgesia that persists after recovery of consciousness. The preparation increases myocardial sensitivity to catecholamines, but to a lesser extent than cyclopropane, halothane.

Side effects methoxyflurane basically similar to those of halothane. Unlike the latter methoxyflurane causes relaxation of uterine muscles and has little effect on uterine contraction during childbirth. In this connection, as well as the analgesic activity methoxyflurane finds use in obstetrics (relatively low concentration). It can be applied through Analgizery.

Note that methoxyflurane may adversely affect renal function: reduced renal blood flow, glomerular filtration, excretion of urine. Therefore, it is relatively rarely used for long-term anesthesia.

Indications are the same as for halothane (except associated with relaxing the influence of halothane on the muscles of the uterus).

Product: in flasks of 10 and 20 ml.

Storage: List B. In the dark spot.