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Description medications: Mesalazine (Mesalazine)

Mesalazine (Mesalazine). 5-aminosalicylic acid.

Synonyms: Asacol, Asalit, Claversal, Fisalamin , Mesacol, Tidocol, Salofalk and others.

The structure is close to the para-amino-salicylic acid (PAS; see sodium para-aminosalicylate.). Different position of NH 2 - group. Antituberculosis activity is not, used for the treatment of acute ulcerative colitis and Crohn's disease. It is part of the molecules salazosulfapiridina (cm.) And its analogs, as used in ulcerative colitis and Crohn's disease.

Like other salicylates, mesalamine is an inhibitor of prostaglandin synthesis and has anti-inflammatory activity. It is possible that it plays a role in its specific action. Mesalazine metabolized in the body to form 5-acetyl-N- aminosalicylic acid.

Assign inside mesalazine in the form of tablets of 0.4 g (400 mg), 3 - 6 times a day.

In applying the drug may nausea, diarrhea, pain in the stomach.

Mesalazine can be used in low efficiency and poor tolerability salazosulfapiridina (sulfasalazine).

Mesalazin strengthens saharoponizhayuschee of sulfonamides, coumarin effects of methotrexate, spironolactone, sulfinpirazona, furosemide, rifampicin. Enhances ultserogennoe glyukskortikoidov impact on the gastric mucosa.

Is contraindicated in case of hypersensitivity to salicylates, when expressed violations of the liver and kidney, gastric ulcer and duodenal ulcer.

Pregnant appoint only for health reasons. You should not assign breastfeeding mothers and children.

Product: pills to 0.4 g (400 mg), coated.