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Description of the medicine: Aceclidinum (Aceclidinum)
ACCELIDIN (Aceclidinum). 3-Acetoxyquinuclidine salicylate.
Synonyms: Aceclidine, Glaucstat (hydrochloride), Glaudin, Glaunorm.
White crystalline powder. Easily soluble in water. Aqueous solutions (pH 4, 5 - 5, 5) are sterilized at +100 ° C for 30 minutes.
It is a cholinomimetic substance that stimulates the predominantly cholinergic systems of the body.
According to its chemical structure, acetylidine belongs to the derivatives of 3-oxyquinuclidine (see also Oxylidin, Imkhin, Temekhin).
He relates it to the molecule of acetylcholine and creates conditions for the binding of acetylidine to cholinergic receptors.
Unlike acetylcholine acetylidine is not a quaternary but a tertiary base, which allows the penetration of acetylidine through the histohematological barriers, including through the blood-brain barrier.
When administered to the body, acetylidine causes an increase in the function of organs that have cholinergic innervation. Particularly expressed ability of the drug to increase tone and strengthen the contraction of the intestine, bladder, uterus. At higher doses, bradycardia, lowering of arterial pressure, increased salivation, bronchiolospasm may be observed. The drug has a strong myotic effect, the narrowing of the pupil is accompanied by a decrease in intraocular pressure. The action of acetylidine is removed and prevented when atropine and other anticholinergic substances are used.
The drug is easily absorbed with different routes of administration, including when instilled in a conjunctival sac.
Azeclidine is used mainly as a means of preventing and eliminating atony of the bladder, especially with an increase in the amount of urine associated with neurogenic disorders of the bladder, with atony of the musculature of the gastrointestinal tract, as well as in obstetric and gynecological practice - with reduced tone and subinvolution of the uterus, To stop bleeding in the postpartum period.
In ophthalmic practice, solutions of acetylidine are used to narrow the pupil and reduce intraocular pressure in glaucoma.
When atony of the stomach, intestines and bladder and hypotension of the uterus, 1 - 2 ml of a 0.2% solution of acetylidine is injected under the skin. If the effect of injection is insufficient, repeat 2 - 3 times with intervals of 20 - 30 minutes. In the presence of indications (with subinvolution of the uterus, etc.), injections of acetylidine are made within 2 to 3 days.
Aceclydine is a valuable pharmacological agent for radiographic examination of the esophagus, stomach and duodenum. To reveal the achalasia of the esophagus caused by parasympathetic denervation, 0.75 - 1 ml of a 0.2% solution of acetylidine is injected under the skin 15 minutes before the patient receives a barium suspension. To clarify the nature of the lesions of the stomach and duodenum, (after a normal X-ray examination) 0.5-1 ml of 0.2% acetylidine solution is injected into the skin, and after 12-15 minutes after the additional portion of the barium suspension is made, a second study is performed.
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