Description of the medicine: Amiridinum (Amiridinum)
AMIRIDIN (Amiridinum). 9-Amino-2, 3, 5, 6, 7, 8-hexahydro-1H-cyclopenta [b] quinoline hydrochloride, monohydrate.
Synonym: Ipidacrine, Ipidacrine.
White fine crystalline powder. Easily soluble in water and alcohol.
It is a reversible inhibitor of cholinesterase and has pharmacological effects characteristic of the drugs of this group. It differs from the usual inhibitors of cholinesterase, however, by stimulating directly the excitation in the nerve fibers and the synaptic transmission in the neuromuscular endings, which is associated with the blockade of the potassium channels of the excitable membranes.
Amiridin enhances the effect on the smooth muscles of not only acetylcholine, but also other mediator substances: adrenaline, serotonin, histamine, oxytocin.
Indications for use are basically the same as for other acetylcholinesterase drugs: neuritis, polyneuritis, myasthenia gravis and myasthenic syndromes, as well as bulbar paralyzes, pareses with organic lesions of the CNS, accompanied by motor disorders. It can also be used for intestinal atony and weakness of labor.
Applied in adults inside and parenteral. Inside appoint 0.01 to 0.02 g (10 to 20 mg) 3 times a day. Under the skin and intramuscularly - from 5 to 15 mg (1 ml of 0.5% - 1 ml of a 1, 5% solution) 1-2 times a day. The course of treatment 1 - 2 months.
For arresting myasthenic crises, parenterally for 1 to 2 ml of a 1, 5% solution (15 to 30 mg) is injected briefly.
Inside with severe disorders of neuromuscular conduction (with myasthenic crises), 1 to 2 tablets (0.02-0.04 g) can be administered up to 5 to 6 times a day.
For the stimulation of labor is prescribed inside once for 1 tablet, and with insufficient effect, 1 tablet twice with an hourly break.
It is also proposed to use amiridin to reduce memory disorders in Alzheimer's disease (see Fizostigmin). The mechanism of action is associated with the stimulation of central cholinergic processes. The question of the effectiveness of the drug and the persistence of the action (as well as with the use of other anticholinesterase drugs) has not been resolved. [Abroad, in addition to physostigmine, the drug tacrin (Tacrin, Tenacrin), close to amiridine in structure, was studied in this way - 9-amino-1 hydrochloride , 2, 3, 4-tetrahydroacridine].
Possible side effects, precautions and contraindications are the same, when using other anticholinesterase drugs (see Physostigmine, Proserin, etc.).
In case of an overdose and an individual hypersensitivity, atropine or methacin is used.
Form release: 0.5% and 1, 5% solutions in ampoules of 1 ml (5 and 15 mg respectively in the ampoule); Tablets of 0.02 g (20 mg) in a package of 50 pieces.
Storage: List B. In dry the dark place.