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Description medications: Tubocurarine chloride (Tubocurarini chloridum)

Tubocurarine chloride (Tubocurarini chloridum) *. d-tubocurarine chloride.

Synonyms: Amelizol, Curadetensin, Curarin, Delacurarine , Myostatine, Myricin, Tubadil, Tubaril, Tubarine, Tubocuran, Kurarin-asta, Intoksotrin and others.

The white crystalline powder. Easily soluble in water. d-Tubocurarine chloride is derived bisbenziltetragidroizohinolina. For a long time it was considered as a base with ammonium bischetvertichnoe optical distance between onium groups (quaternary nitrogen atoms), 1, 5 nm, the structure shown in formula top.

However, in 1970 it published the results of chemical and spectroscopic studies, which showed that one molecule of nitrogen atoms d-tubocurarine is not quaternary and tertiary. Thus, d-tubocurarine should not be seen as a bischetvertichnoe but as monochetvertichnoe connection. d-blocks Tubakurarin predominantly n-holinoreaktivnye skeletal muscle, to a lesser extent affect cholinergic receptors of autonomic ganglia. In high doses, this drug also blocks cholinergic autonomic ganglia, the adrenal chromaffin tissue and the carotid glomeruli.

Small doses of d-tubocurarine manages to cause a temporary relaxation of skeletal muscles (relaxation).

At the same time the muscles relax as follows: muscles of the fingers - eyes - feet - neck - back then the intercostal muscles and the diaphragm.

When receiving low doses of respiratory arrest can not take place (if not blocked nerve transfer to the intercostal muscles and the diaphragm), but with increasing doses there is respiratory arrest; if produced mechanical ventilation, the effect of d-tubocurarine gradually passes and recovering natural breathing.

At the same time the restoration of muscle function occurs in the reverse order of their relaxation. With adequate mechanical ventilation d-tubocurarine does not cause violations of basic body functions.

On the d-tubocurarine expressed directly not affected the cardiovascular system, but due to ganglioblokiruyuschim action can cause a decrease in blood pressure (usually 15 - 20 mm Hg..). On the central nervous system d-tubocurarine in normal doses has no significant effect. Note that d-tubocurarine promotes the release of histamine from the tissues and can sometimes cause spasm of the bronchial tubes myshsch. d-Tubocurarine anesthesiologists used mainly as a muscle relaxant, causes muscle relaxation during surgery.

The trauma is sometimes used by d-tubocurarine to relax the muscles at the repositioning of bone fragments, reposition the complex contortions and so. N.