Description of the medicine: Ethosuximide (Ethosuximidum)

ETOSUXIMID (Ethosuximidum). 3-Ethyl-3-methylpyrrolidin-2, 5-dione, or a-ethyl-a-methylsuccinimide.

Synonyms: Asamide, Pycnoleptsin, Ronton, Suxilep, Etomal, Aethosuximid, Asamid, Ethymal, Etomal, Pemalim, Petinimid, Pyknolepsin, Ronton, Succimal, Suxilep, Zarontin and others.

Has anticonvulsant activity, manifested, like in trimetine, with small forms of epilepsy. It is also effective in myoclonic seizures. Somewhat less toxic than trimethine.

Assign inside (take while eating). The initial daily dose for children is 0.25 g, for older children and adults 0.25-0.5 g per day with a gradual increase in the dose for adults to 0.75-1 g per day (in 3 to 4 doses).

The drug has an analgesic effect in the trigeminal neuralgia (see Karbamazepine), but somewhat less effective than carbamazepine. Assign a dose of 0.25 g, gradually increasing the dose to 0.5 - 1 g per day. A maintenance dose of 0.25 g per day.

Possible side effects: gastrointestinal disorders, in rare cases - headache, dizziness, skin rash, photophobia. There may be phenomena of parkinsonism. The possibility of neutropenia, agranulocytosis, albuminuria is not ruled out.

During the treatment it is necessary to perform blood and urine tests.

It should be taken into account that the drug can provoke the appearance of large seizures of epilepsy.

Ethosuximide penetrates the placental barrier into the milk of lactating women. Therefore, pregnant and lactating breast is not recommended to prescribe the drug.

Forms of production: under the name "Suxilep" is produced in capsules of 0.25 g (in a package of 100 and 150 pieces) and in the form of a solution containing 5 grams of the drug in 100 ml, 25 g of glycerin and 25 ml of a water-alcohol mixture 50 g bottles); 15 drops of the solution contain 0.25 g of ethosuximide.

Storage: List B.