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Description medicines: Clonazepam (Clonazepamum)

Clonazepam (Clonazepamum). 7-Nitro-2, 3-dihydro-5- (o-chlorophenyl) -1H-1, 4-benzodiazepin-2-one.

Synonyms: Antelepsin, Antelepsin, Clonazepan, Clonopin, Iktoril , Iktorivil, Ravatril, Ravotril, Rivatril, Rivotril and others.

Clonazepam is similar in structure to nitraeepamu (cm.), From which it differs only by the presence of the chlorine atom in the 2-position of the phenyl nucleus.

Like the group of tranquilizers dibenzoazepina, clonazepam has a calming, muscle-relaxing, anxiolytic and anticonvulsant effect. The anticonvulsant effect of clonazepam expressed in stronger than the other drugs in this group, in connection with which it is used mainly for the treatment of convulsive states. In patients with epilepsy taking clonazepam, attacks occur less often and their intensity is reduced.

The drug is rapidly absorbed. After oral administration the peak plasma concentration observed in 1 - 2 hours.

The drug has long-term. organnzme half-life is 18 - 20 hours. Write mainly in urine.

Apply clonazepam in children and adults with small and large forms of epilepsy with myoclonic seizures, with psychomotor crises, increased myshechom tone. Also used as a hypnotic, especially in patients with organic brain lesions.

Clonazepam Treatment starts with small doses, gradually increasing them to optimum effect. Dosage individually depending on the patient and his reactions to the drug. The drug is administered at a dose of 1, 5 mg per day, divided into 3 doses. Gradually increase the dose of 0.5 - 1 mg every third day until an optimum effect. Typically prescribed 4 - 8 mg per day. Do not exceed the recommended dose of 20 mg per day.

Children clonazepam designate in the following doses: infants and children up to 1 year - 0.1 - 1 mg per day, from 1 to 5 years - 1, 5 - 3 mg per day, from 6 to 16 years - 3 - 6 mg day. The daily dose divided into 3 admission.

Before the drug can ataxia, irritability, depressive effects, fatigue, and nausea. To reduce the side effects need to individually select the optimal dose, starting with lower doses and gradually increasing them.

Contraindications and precautions are the same as with other benzodiazepines (see.).

The drug crosses the placental barrier and into breast milk. It should not be given to pregnant and breast-feeding.

Product: pills to 0,001 grams (1 mg) in a package of 30 or 50 pieces.

Storage: List B.