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Description medications: Ketotifen (Ketotifenum)

Ketotifen (Ketotifenum) *. 4, 9-Dihydro-4- (1-methyl-4-piperidinylidene-10H-benzo [4, 5] cyclohepta [1, 2-b] -thiophene-10-one [fumarate).

Synonyms: Astafjevs, Zaditen, Asmasedil, Asmen, Astafen, Histaten , Ketotisin, Poziten, Respimex, Totifen, Zaditen, Zasten.

The drug has antihistaminic and antiallergic activity. Action is associated with the ability to inhibit the release of histamine and other mediator substances ( "slow reacting substance of anaphylaxis", lymphokines, etc..) From mast cells, inhibit platelet activating factor induced accumulation of eosinophils in the airways, have a blocking effect on the receptors.

The drug is well absorbed in the peak plasma concentration observed after 2 - 4 hours after ingestion, half life reaches 21 hours.

Applied for the treatment (mainly for the prevention of attacks), bronchial asthma, allergic bronchitis, hay fever, allergic rhinitis, allergic skin reactions.

Assign into adults and 0,001 grams (1 mg) in the form of capsules or tablets, 2 times a day (morning and evening during meals). If necessary, take 2 mg 2 times a day.

Children, depending on the age and body weight are administered in smaller doses (1/3 - 1/2 - 2 1 tablet twice a day).

The drug may have sedative effects, and should be administered with caution transport drivers, operators, and so on. D. It should be noted that the drug increases the effects of hypnotics, sedatives and alcohol. Reduction of the amount of platelets.

The drug is contraindicated in pregnancy. You should not assign it simultaneously with oral anti-diabetic and other drugs that can cause thrombocytopenia. Individuals sensitive to the sedative action, prescribe the drug in the first week of treatment in small doses - 0.0005 g (0.5 mg) per day.

Product: capsules and tablets of 0.001 g (1 mg); syrup containing 1 ml of 0.2 mg (100 mg 20 ml).

Storage: List B.