Description of the medicine: Aluminum hydroxide (Aluminii hydroxydum)
ALUMINUM HYDROOKIS (Aluminii hydroxydum).
Synonyms: Aluminum hydroxydatum, Aluminium hydroxyde.
Amorphous loose white powder, practically insoluble in water and capable of forming a gel; Is soluble when heated in dilute acids and solutions of caustic alkalis.
Has antacid, adsorptive and enveloping properties
The drug neutralizes hydrochloric (hydrochloric) acid (1 g neutralizes about 250 ml of 0.1 N hydrochloric acid solution) to form aluminum chloride and water; The pH of the gastric juice gradually increases to 3, 5 4, 5 and remains at this level for several hours. At this pH value, not only the acidity of the gastric juice decreases, but its peptic (proteolytic) activity is strongly inhibited. In the alkaline contents of the intestine of aluminum, chloride forms insoluble (and nonabsorbable) aluminum compounds (phosphates, etc.) and chlorine ions. Chlorine ions are reabsorbed, so alkalosis does not develop.
Inside, aluminum hydroxide is prescribed in cases of increased acidity of gastric juice, peptic ulcer of the stomach and duodenum, acute and chronic hyperacid gastritis and food poisoning.
Inside appoint in the form of suspensions (4%) in water, usually 1 - 2 teaspoons 4 - 6 times a day.
At present, other preparations containing aluminum, including combined dosage forms, have become more widely used (see Almagel, Gastal, etc.).
When using aluminum hydroxide, development of constipation is possible. In combination with magnesium oxide (see Gastal), the antacid effect is enhanced and the possibility of constipation decreases.
Due to the fact that aluminum hydroxide binds phosphates and delays their absorption from the gastrointestinal tract, it finds application in the case of hyperphosphatemia accompanying renal failure. However, there are indications that in severe violations of kidney function, aluminum preparations are contraindicated.
Aluminum hydroxide is sometimes used as an astringent external to skin diseases.