Description of the medicine: Aminazine (Aminazinum)
Aminazine (Aminazinum). 2-Chloro-10- (3-dimethylaminopropyl) phenothiazine hydrochloride.
Synonyms: Plegomazine, Chlorpromazine, Ampliactil, Amplictil, Chlorazin, Chlorpromazini hydrochloridum, Chlorpromazine hydrochloride, Chlorpromazine, Contomin, Fenactil, Hibanil, Hibernal, Kloproman, Largactil, Megaphen, Plegomazin, Promactil, Propaphenin, Thorazine, etc.
White or white with a weak cream shade of fine crystalline powder. Slightly hygroscopic. It gets dark in the light. Very easily soluble in water. Powder and aqueous solutions darken under the influence of light. Solutions have an acid reaction; PH 2, 5% solution 3, 5 - 5, 5.
Sterilization of aqueous solutions can be performed at +100 C for 30 minutes, but they are usually not sterilized, as they themselves have bactericidal properties.
Solutions of aminazine (and other phenothiazine preparations) are incompatible with solutions of barbiturates, carbonates, Ringer's solution (precipitation).
Aminazine is one of the main representatives of neuroleptics. Despite the emergence of numerous new neuroleptic drugs, it continues to be widely used in medical practice.
One of the main features of the action of aminazine on the central nervous system is a relatively strong sedative effect. Growing with an increase in the dose of aminazine, the general calm is accompanied by inhibition of conditioned reflex activity and, first of all, motor-defensive reflexes, a decrease in spontaneous motor activity and a certain relaxation of skeletal muscles; There comes a state of reduced reactivity to endogenous and exogenous stimuli; Consciousness, however, persists. At high doses, the state of sleep can develop.
Aminazine enhances the effect of sleeping pills, drugs, analgesics, and local anesthetic substances. He oppresses various interoceptive reflexes.
The action of anticonvulsants under the influence of aminazine increases, but in some cases, aminazine can cause convulsive phenomena.
The drug has a strong antiemetic effect and soothes hiccup (see also etaperazin).
Aminazine has a hypothermic effect, especially with artificial cooling of the body. In some cases, patients with parenteral administration of the drug body temperature increases, which is due to the influence on the centers of thermoregulation and partly local irritant effect.
The drug also has moderate anti-inflammatory properties, reduces vascular permeability, reduces the activity of kinins and hyaluronidase. Has a weak antihistamine effect.
An important property of aminazine is its blocking effect on central adrenergic and dopaminergic receptors. It reduces or even completely eliminates the increase in blood pressure and other effects caused by adrenaline and adrenomimetic substances. Hyperglycemic effect of epinephrine with aminazine is not removed. Strongly expressed central adrenolytic action. The blocking effect on cholinergic receptors is relatively weak.