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Description of the medicine: Acetylcystein (Acetylcysteinum)

ACETYL CYSTEINE (Acetylcysteinum).


Synonyms: Broncholysin, Mucosolvin, Acetein, Acetulcysteine, Ayrbron,

Broncholysin, Fluimucetin, Fluimucil, Inspir, Mucisol, Mucofilin, Mucolu ticum, Mucomyst, Mucosolvin, Racomex and others.

White or white with a slightly yellowish tinge crystalline powder, with a weak specific odor. Easily soluble in water and alcohol; PH 20% of the aqueous solution 7, 0 - 7, 5.

It is derived from the amino acid cysteine ​​(see), from which acetyl cysteine ​​differs in that one hydrogen of the amino group is replaced by an acetic acid residue.

Acetylcysteine ​​is an effective mucolytic (secretolithic) drug.

Diluting sputum and increasing its volume, acetylcysteine ​​facilitates its isolation; Contributes to expectoration, also reduces inflammation.

The effect of the drug is due to the ability of its free sulfhydryl groups to disrupt the disulfide bonds of acid mucopolysaccharides of moxa, which leads to depolarization of mucoproteins and a decrease in mucus viscosity. The drug also liquefies pus.

Applied with diseases of the respiratory system, accompanied by increased viscosity of sputum with the attachment of purulent infection (acute and chronic bronchitis, pneumonia, bronchiectasis, cystic fibrosis, etc.). They are prescribed for prevention of complications during operations on the respiratory organs, as well as after endotracheal anesthesia. It is also recommended for bronchoscopy to flush the bronchial tree.

The drug is effective for infectious allergic bronchial asthma, complicated by bacterial, especially purulent, bronchitis or suppurated bronchiectasis. However, in these cases, caution should be exercised in connection with the possibility of strengthening bronchiolospasm. Preventively, it is advisable to simultaneously take bronchodilators. "

Apply acetylcysteine ​​in the form of inhalation of 2 - 5 ml of 20% solution 3-4 times a day (for 15-20 minutes); Intra-tracheal administration of 1 ml of 10% solution every hour (in the form of slow instillation); 5 - 10% solutions are used to flush bronchial tubes with medical bronchoscopy. + If the acetylcysteine ​​solution can not be administered in the form of inhalations and intratracheal (for injuries to the respiratory tract, coma), and also in pediatric practice, the drug is administered intramuscularly.

Adults injected intramuscularly 1 - 2 ml of 10% solution 2 - 3 times a day; Infants - at a rate of 10 - 15 mg / kg 2 times a day; Children older than 1 year - 0.5 - 1 ml 10% solution 2 times a day.

The duration of treatment depends on the nature and course of the disease; Usually the course of treatment lasts 1 to 2 weeks; With tracheobronchitis - 3 - 4 days, with cystic fibrosis - 7 - 10 days.

If necessary, administer the drug intravenously. Adult dose 0.5 g (10 ml of 5% solution). After 30 to 90 minutes after administration, sputum separation is facilitated, which is removed by coughing or suctioning. The effect of the drug in a single dose lasts 2-4 hours. For course treatment, 10 ml of a 5% solution are administered twice a day for 7-10 days.