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Description medications: Ornid (Ornidum)

Ornid (Ornidum).

Ortho-N-Bromobenzyl bromide etildimetilammoniya.

Similar p-toluene-sulfonate (or tosylate) are produced abroad under the title: Bretylan, Bretylat, Bretylin, Bretylii tosilas, Bretylium tosilate, Darenthin and others.

The white crystalline powder and odorless. The easily soluble in water, alcohol. Hygroscopic.

Ornid refers to a group of sympatholytic agents (see. Oktadin, reserpine). However, it has potent anti-arrhythmic activity.

On the mechanism of sympatholytic actions ornid differs from reserpine and oktadin. Sympatholytic effect is associated with the blocking norepinephrine release from presynaptic nerve terminals and reduction concerning influence on neurotransmitter adrenoceptors. Ornid directly blocking effect on the adrenergic receptors has not.

Ornid mainly used as an antiarrhythmic. It increases the refractory period and is particularly effective for ventricular arrhythmia origin.

To some extent, the antiarrhythmic effect Ornid due to weakening adrenergic effects on the myocardium. It has also been suggested that the basis for action antifibrillyatornogo Ornid (and other simpatolitikov) is blockage of potassium channels of cardiomyocytes, leading to the accumulation of intracellular potassium ions.

As sympatholytic, ornid lowers blood pressure; earlier it was offered as an antihypertensive agent. However, the hypotensive effect is expressed in his moderate.

Assign ornid with ventricular arrhythmias: ventricular tachyarrhythmia, arrhythmia (especially when resistance to other medications).

For relief of arrhythmia is administered intravenously or intramuscularly at a rate of 0.1 mL of 5% solution (5 mg) per 1 kg of body weight; for the prevention of arrhythmias is administered intramuscularly in 0.5 - 1 ml of a 5% solution 2 - 3 times a day.

With the introduction of the drug may orthostatic hypotension, as well as general weakness, feeling of fever, swelling of the nasal mucosa, sometimes a temporary loss of vision, a sense of tension and pain in the calf muscles.

Contraindications: acute cerebral circulatory disorders, hypotension, severe renal insufficiency.

Product: 5% solution in 1 ml ampoules in a package of 10 vials.

Storage: List B. In the dark spot.