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Description of the medicine: Euphyllinum


Theophylline with 1, 2-ethylenediamine. Theophylline content is about 80%, ethylenediamine is 20%.

Synonyms: Aminophylline, Aminocardol, Aminophyllinum, Ammophyllin, Diaphyllin, Genophyllin, Methaphyllin, Neophyllin, Novphyllin, Synthophyllin, Theophyllamin, Theophylline ethylendiamine, and others.

White or white with a yellowish tinge crystalline powder with a faint odor of ammonia. Soluble in water. Aqueous solutions (pH 9, 0 9, 7) are prepared aseptically.

The effect of euphyllin is due primarily to the content of theophylline in it. Ethylenediamine increases spasmolytic activity and promotes dissolution of the drug. The molecular mechanism of the action of euphyllin is basically similar to the mechanism of action of theophylline.

Important features of euphyllin are its solubility in water and the possibility of its parenteral (intravenous) administration.

Like theophylline, euphyllin relaxes the muscles of the bronchi, lowers the resistance of the blood vessels, dilates the coronary vessels, lowers the pressure in the pulmonary artery system, increases the renal blood flow, has a diuretic effect, associated mainly with lowering tubular reabsorption; Causes an increase in excretion of urine and water electrolytes, especially sodium and chlorine ions.

The drug strongly inhibits the aggregation of platelets.

Apply eufillin with bronchial asthma and bronchiolospasm of various etiologies (mainly for relief of seizures); Hypertension in the small circle of blood circulation, as well as with cardiac asthma, especially when attacks are accompanied by bronchiolospasm and respiratory disorders of the Cheyne Stokes type. It is also recommended for arresting cerebral vascular crises atherosclerotic origin and improving cerebral circulation, reducing intracranial pressure and cerebral edema in ischemic strokes, as well as with chronic cerebral circulatory failure. The drug improves renal blood flow and can be used in the presence of appropriate indications.

Assign eufillin inside, in muscles, veins and microclysters. Under the skin, solutions of euphyllin are not administered, since they cause irritation of the tissues.

The method of administration depends on the features of the case: in acute attacks of bronchial asthma and strokes, intravenously, in less severe cases, intramuscularly or inward.

Inside adults take 0.15 g after meals 1 to 3 times a day. Children inside are given at a rate of 7 to 10 mg / kg per day in 4 divided doses. The duration of the course of treatment is from several days to several months.

In the vein, adults are slowly administered (for 4-6 minutes) to 0.12 0.24 g (5-10 ml of a 2, 4% solution), which are previously diluted in 10-20 ml of isotonic sodium chloride solution. When there is a palpitations, dizziness, nausea, the speed of administration slows down or goes to a drop introduction, for which 10 - 20 ml of a 2, 4% solution (0.24 0.48 g) is diluted in 100-150 ml of isotonic sodium chloride solution; Injected at a rate of 30-50 drops per minute. If it is impossible to insert into the vein, intramuscularly inject 1 ml of 24% solution.