Description medications: Angiotensinamide (Angiotensinamidum)
Angiotensinamide manufactured for medical use in a formulation for injection (Angiotensinamidum Pro injestionibus) is an L-asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-Lgistidil-L-prolyl-L-phenylalanine acetate.
Synonyms: IL-asparagyl-5-L-valyl-angiotensin II, Gipertenzin, Nurertensin.
White lyophilized powder with a weak smell of acetic acid. Easily soluble in water, a little - in alcohol.
Angiotensinamide has a strong pressor effect caused by the increase in peripheral resistance of blood vessels, especially small caliber arterioles. In the tone of veins affect slightly.
Influenced Angiotensinamide particularly strongly narrowed blood vessels of the internal organs, skin and kidneys. Circulation in skeletal muscle and coronary blood vessels did not significantly change. Direct effect on the heart and does not render the drug at therapeutic doses do not cause arrhythmia.
The drug also has the ability to reduce the smooth muscles of the uterus, intestines, bladder and gall bladder. It stimulates the release of adrenaline from the adrenal glands and the production of aldosterone.
Angiotensinamide rapidly inactivated by enzymes contained in the blood, in connection with which a single administration provides short (2 - 3 min) pressor effect. However, the duration of effect may be relatively easily adjusted by choosing the appropriate speed injection solution (intravenous drip).
Apply in state of shock, especially when isovolemic shock associated with vasomotor collapse (post-traumatic and post-operative shock, shock with intoxication, komah and infectious diseases, as well as myocardial infarction, cardiac tamponade, massive pulmonary embolism, and so on. D.). In cardiogenic shock, in cases involving the reaction of peripheral vascular constrictor, the drug should be used with caution (see. Norepinephrine).
Enter intravenously by slow drip infusion.
To dissolve the lyophilized Angiotensinamide used isotonic sodium chloride solution or 5% solution glyunozy.
Of the total amount of solvent required for the infusion, 10 ml syringe and gain introduced through the rubber stopper of the vial with Angiotensinamide. The contents of the vial thoroughly shaken until complete dissolution of the powder. Then, this solution was transferred by syringe to the remainder of the solvent.
Due to the presence in the blood enzyme angiotensinase, the drug should not be diluted by blood and blood serum. Depending on the rate of administration, the drug solution is prepared at a concentration of 1 to 50 mg in 1 ml (for the slow introduction - low concentrations).
To prepare a concentration of 1 ug / ml of the contents of one vial (1 mg) was dissolved in 1000 ml of solvent, and for a concentration of 50 ug / ml - 20 ml of solvent.