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Description of the drug: Amyloride (Amiloridum)


N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride.

Synonyms: Amilorid hydrochloride, Amipramidine, Amiprazid, Arumil, Cofectril, Diursan, Guanamprazine, Medamor, Midamor, Modamide, Nilurid, Pandiuren and others.

Acts mainly on the distal part of the renal tubules, enhances the release of sodium and chlorine ions and reduces the release of potassium ions. Has a diuretic effect, but less potent than thiazide diuretics.

The action begins 2 hours after ingestion and lasts up to 24 hours.

Applied mainly in combination with other diuretics (dichlorothiazide, etc.). Amyloride enhances their diuretic effect and reduces the risk of hypokalemia.

Assign inside 2, 5 - 5, 0 - 20.0 mg per day (not more than 40 mg per day).

Product: tablets of 0.025 g (2.5 mg) and 0.005 g (5 mg).

Under the name "Moderetik" (the name of the drug of the company "MERKK & CO., INS.", Rahwau, NJ, US A.) (Moduretic), a combined preparation is prepared - tablets containing 50 mg of hydrochlorothiazide (dichlorothiazide) and 5 mg of amiloride. Take 1 - 2 tablets up to 4 times a day.