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Description of the drug: Somatotropinum humanum

SOMATOTROPIN (human) (Somatotropinum humanum).

Hormone of the anterior lobe of the human pituitary gland.

Synonyms: Growth Hormone, Somatropin, Humatrop, Asellacrin, Crescormon, Genotropin, Humatrop, Nanormon, Somatonorm, STH, Somatropin.

It is a polypeptide consisting of 191 amino acid residues.

Has an anabolic effect, positively affects the mineral metabolism, causes an increase in body height and body weight due to dwarfism associated with insufficiency of growth hormone.

In the past, for medical use, somatropin was given for injection, isolated from the pituitary gland.

Recently (1998), this drug is excluded from the nomenclature and replaced with somatotropin drugs obtained by genetic engineering (Sizen, Genotropin, Humatrop, Norditropin, etc.).

Indications for the use of somatotropin drugs are the developmental disorders associated with insufficiency of growth hormone (pituitary dwarfism, pituitary fascism).

The drugs of this group are contraindicated in malignant neoplasms.

Saizen.

A growth hormone, obtained by genetic engineering (using mammalian animal cells).

It causes an increase in body height and body weight (mainly in patients with growth retardation associated with impaired secretion of endogenous growth hormone).

Indication for use - see Somatotropin.

Enter intramuscularly or subcutaneously. Daily applied at the rate of 12 ED (ME) per 1 m2 of the body surface (0.6 U / kg). In the absence of effect, the dose is increased to 20 U / sq. M (or 0.8 U / kg).

With intramuscular injection, the weekly dose is divided into 3 single injections (4 U / m2 or 0.2 U / kg) and injected every other day (usually in the evening).

With subcutaneous administration, the weekly dose is divided into 6-7 single doses.

Treatment is carried out for a long time (under careful clinical and laboratory control).

There are indications that after a 12-month administration of saisen there is a significant increase in the growth rate of the children's body.

Form release: lyophilized powder in vials of 4 or 10 IU.

Storage: at a temperature of +2 to +8 C (in the refrigerator).

Genotropin (Genotropin).

A variety of recombinant (obtained by genetic engineering using Escherichia coli) somatotropin.

Indications for use - see Somatotropin.

Enter under the skin. The dose is selected individually. Usually used at the rate of 12-16 IU per 1 m 2 of the body surface or 0.5-0.7 mg per 1 kg of body weight per week. This dose is divided into 6-7 inentsii (1 time per day).

Product: special two-piece cartridges (cartridges) containing 16 IU of lyophilized somatotropin powder (genotropin) in one section, in the other - a solvent. Enter with the help of a special syringe.

Humatrop (Humatrop) is available in 4U vials (lyophilized powder for injection) and 18 and 36 IU in a special dosage form (3 ml cartridges).

Norditropin (Norditropin) - in bottles of 12 and 24 IU.

Indications for use - see Sizen.