Description of the medicine: Butamidum
N- (p-Methylbenzenesulfonyl) -N-n-butyl-urea:
Synonyms: Aglycid, Arcosal, Artosin, Beglucin, D-860, Diabecid R, Diabetamid, Diabetol, Dirastan, Dolipol, Mobenol, Neoinsoral, Orabet, Oresan, Orinase, Rastinon, Tolbusal, Tolbutamide, Tolbutamidum, Tolumid, Toluvan, etc.
White crystalline powder slightly bitter taste. Almost nerastvorim in water, soluble in alcohol.
It is one of the main representatives of oral hypoglycemic derivatives of sulfonylurea. The antipyretic effect of the drug is most pronounced in the first 5-7 hours after administration and lasts up to 12 hours (after a single dose).
Like other drugs of this group, it is used mainly in type II diabetes mellitus.
Assign inside. At the beginning of the treatment, 2 grams per day are given, with 1 g (2 tablets of 0.5 grams) the patient takes in the morning an hour before meals (usually at 7-8 in the morning) and 1 g at 5-6 in the evening. Increasing the dose of more than 2 g to increase the effect usually does not.
The therapeutic effect of the drug is usually manifested during the first 2 to 3 weeks (in some patients during the first week). After elimination of glucosuria and normalization of blood glucose level after 2 weeks, the dose can be reduced to 1 g in the morning and 0.5 g in the afternoon, while maintaining good performance after the same period - up to 0.5 g in the morning and 0.5 G in the afternoon. For at least 1 month continue taking the drug at this dose, and later, with good results, reduce the daily dose to 0.5 or 0.25 g or less (depending on the results of the studies).
In mild cases of the disease, treatment can be started with a dose of 0.5 g 2 times a day, followed by a rise with an inadequate effect.
When transferring to treatment with butamide of patients receiving insulin (when the compensation of violations of carbohydrate metabolism is reached by insulin in doses less than 40 units per day), butadam is prescribed in a dose of 1 g 2 times a day, and insulin dose is reduced by half. Further refinement of the dose of insulin, its reduction or elimination of the drug is made under the control of urine (glucose and acetone) and blood (glucose) tests. If less than 10 units of insulin per day is required to compensate for diabetic disorders, it can be canceled immediately and a 1 g dose of butadin 2 times a day is prescribed. If in the first weeks of treatment with butamide ginerglikemia and glucazurin are not eliminated, you should switch to treatment with a more active drug or a combination of sulfanilamide with biguanidine, and if there is no compensation for metabolic disorders, you need to switch to insulin treatment.
Higher doses of butamide for adults inside: single-dose 1, 5 g, daily 4 g.
Treatment with butamide is performed under close supervision of the doctor; Patients must follow a diet; It is systematically necessary to examine the glucose level in the blood (in the morning on an empty stomach) and in the daily urine; Before the start of treatment and at first time these studies are performed daily. During the treatment, it is necessary to systematically produce a common blood test.