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Description of the medicine: Meprotanum


Dicarbamate 2-methyl-2-propylpropanediol-1, 3.

Synonyms: Meprobamate, Andaxin, Aneural, Biobamat, Equanil, Gadexyl, Harmonin, Mepavlon, Meprobamatum, Meprobamate, Meproban, Meprospan, Miltown, Nephentine, Pankalma, Pertranquile, Procalmadiol, Quanil, Restenil, Sedanyl, Sedazil, Sedral, Tensonal, Tranquil, Tranquilan, Tranquiline, Tranquisan et al.

White crystalline powder. Slightly soluble in water, easily - in alcohol.

Meprothan (meprobamate) is considered the ancestor of tranquilizers (<small> tranquilizers). It was synthesized in the search for central muscle relaxants. The first preparation of this group was 3- (ortho-toloxy) -1, 2 propanediol, or mianesine (synonyms: Mephenesin, Tolserol, etc.), but due to short duration, low oral efficacy and relatively high toxicity, As a medicine.

Meprothane was more active, effective in ingestion and much less toxic. Along with the muscle relaxant effect associated with inhibition of excitation transfer in the area of ​​intercalary neurons of the spinal cord, thalamus and hypothalamus, it has a general calming effect on the central nervous system, enhances the effect of hypnotics and analgesics, and has anticonvulsant activity.

On the vegetative department of the nervous system, the meprotan has no pronounced influence; Does not directly affect the cardiovascular system, breathing, smooth muscles; Slightly lowers body temperature.

Meprothan is effective as a sedative mainly in neuroses and neurosis-like conditions and has found wide application in medical practice.

Apply mepatrogen in neuroses and neurosis-like conditions, which occur with irritability, excitement, anxiety, fear, affective tension, sleep disorders, with psychoneurotic conditions associated with severe somatic diseases, as well as in diseases accompanied by increased muscle tone, joint diseases with muscle spasms .

In psychiatric practice in acute psychotic states with productive psychopathological disorders, meprotan is ineffective.

As a soothing agent can have a beneficial effect in autonomic dystonia, premenstrual symptom complex, menopause, the initial forms of hypertension, gastric ulcer, skin itching, etc. In sleep disorders, meprotan can be used alone and in combination with hypnotics.

In surgical practice, meprotan is used in preparation for surgical interventions to reduce the fear of the operation, for some reduction in muscle tension.

Assign inside (after eating) in tablets at a dose of 0.2 - 0.4 g for taking 2 - 3 times a day. The daily dose, if necessary, can be increased to 2 - 3 g. When insomnia take 0.2 - 0.4 - 0.6 g before bedtime.

Higher doses for adults inside: single 0.8 g, daily 3 g.

For children, the drug is prescribed in smaller doses: at the age of 3 - 8 years - 0.1 - 0.2 g 2-3 times a day, 8-14 years - 0.2 g 2 - 3 times a day. The course of treatment continues on average 1 to 2 months.