Description of the medicine: Cobamamidum (Cobamamidum)
Co a - [a - (5, 6-dimethylbenzimidazolyl)] - Co b-adenosylcobamide.
Synonyms: Adenosylcobalamin, Adenosylcobalamin, Cobamamidum dibencozide, Coenzym B12.
Dark red crystalline powder. Hygroscopic. Soluble in water; Almost insoluble in alcohol.
Chemically, cobalamid differs from cyanocobalamin in that the cobalt atom is covalently bound not to the cyano group, but to the b-5'-deoxyadenosyl residue.
Cobamamide is a coenzyme form of vitamin B 12, that is, one in which cyanocobalamin should be converted to provide its physiological (and curative) effects.
Like cyanocobalamin, cobalamin participates in a number of biochemical reactions that ensure the vital functions of the organism (in the transfer of methyl groups, in the synthesis of nucleic acids, proteins, in the exchange of amino acids, carbohydrates, lipids, etc.). It has a curative effect not only in B 12 deficiency anemia, but also in diseases of the nervous system, hypotrophic processes, etc. The drug has anabolic activity.
Applied as an anabolic agent in low birth weight infants and hypotrophy, in young children with reduced appetite and reduced body weight, in adults with anorexia nervosa and asthenia. Also used in diseases of the peripheral nervous system (neuralgia, traumatic injuries, etc.); In 12-deficiency anemia in the complex treatment of liver diseases (chronic hepatitis, cirrhosis, fatty degeneration), chronic enterocolitis, etc.
Cobamamide is administered orally or parenterally (intramuscularly, subcutaneously, intravenously).
Children inside appoint 0.0002 g (200 mcg) - 0.0005 g (500 mcg) 2-5 times a day (half an hour before meals). For ease of use, dissolve the tablet (without the coating) in a 5% solution of glucose or boiled water (25-50 ml). The dose for adults is 0.0005 - 0.001 grams 1 to 6 times a day. The course of treatment usually lasts 7 - 30 days.
Children are administered intravenously or intramuscularly once a day at 0.0005 g per injection; Course of treatment 7 - 10 days.
Adults with a syndrome of anorexia nervosa and asthenia appoint inward to 0.0005 - 0.001 g 3 - 6 times a day (daily dose to 0.003 g). The course of treatment from 1 to 3 months.
In diseases of the peripheral nervous system, In 12-deficient anemias, chronic lymphocytic leukemia is administered intramuscularly to 0.0005 0.001 g (500-1000 mcg) once a day daily for a month, or 0.0005 to 0.0015 g every other day At В 12 deficiency anemia). The course of treatment 20 - ZO injections. If necessary, after 2-6 months, repeat the course.
In complex therapy of chronic hepatitis, fatty liver disease, cirrhosis, chronic pancreatitis and enterocolitis, coamine is administered intramuscularly at a dose of 0.00025-0.0005 g (250-500 mcg) once a day after 3 days; For a course of 10 to 15 injections.
There are data on the effectiveness of kobamid in the complex therapy of inflammatory and dystrophic myocardial lesions.