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Description medications: Folic acid (Acidum folicum)

Folic acid (Acidum folicum). [The name "folic acid" (from folium - leaf) due to the fact that it was originally isolated from spinach leaves.].

N- [4 - [(2-Amino-1, 4-dihydro-4-oxo-6-pteridil) methyl] amino] benzoilL (+) - glutamic acid.

Synonyms: Vitamin B, Pteroilglutaminovaya acid, Cytofol, Folacid, Folacin, Folamin , Folcidin, Foldine, Folic Acid, Folicil, Folsan, Folvit, Millafol, Piofolin and others.

Folic acid is a vitamin group B. It is found in fresh vegetables (beans, spinach, tomatoes, etc.) And in the liver and kidneys of animals. formed intestinal microflora in the human body.

For medical purposes, prepared synthetically. The synthetic drug is a yellow or yellow-orange crystalline powder. Practically insoluble in water and alcohol; easily soluble in solutions caustic alkalis. Hygroscopic. Decomposes in the light.

In the body, folic acid is reduced to tetrahydrofolic acid, a coenzyme participating in various metabolic processes. It is essential for the normal formation of blood cells, including the processes of maturation and education megaloblasts normoblasts.

Lack of folic acid slows the transition phase megaloblastic hematopoiesis in normoblasticheskuyu.

Together with vitamin B 12 stimulates erythropoiesis, it is also involved in the synthesis of amino acids (methionine, serine, etc.), Nucleic acids, purine and pyrimidine metabolism in choline.

Applied to stimulate erythropoiesis when makrotsitarnyh anemia (megaloblastic anemia in pregnant women, and others.), As well as sprue. In the treatment of aplastic anemia drug ineffective. When sprue folic acid reduces or eliminates the clinical manifestations of the disease, it normalizes blood (in this disease at the same time appoint cyanocobalamin and ascorbic acid, liver drugs, gene therapy). Folic acid is also used in anemia and leukopenia caused by medicinal substances and ionizing radiation, with anemia resulting from resection of the stomach and intestines, with nutritional anemia makrotsitarnyh newborns. In connection with a favorable effect on the intestinal function it is recommended to treat chronic gastroenteritis and intestinal tuberculosis.

In pernicious anemia, folic acid should be used only in conjunction with vitamin B 12. Although folic acid may improve some blood, it does not prevent the development of neurological complications (funicular myelosis et al.).

For the prevention of folic deficiency associated with an unbalanced or inadequate diet, prescribe folic acid inside of 20 - 50 mg daily. During pregnancy take 400 micrograms per day while breastfeeding - 300 mcg.

With the purpose of treatment is prescribed for adults of 0,005 grams (5 mg) per day, children - in smaller doses depending on age. The duration of treatment 20 - 30 days.