Description medications: Alfacalcidol (Alfacalcidol)
9, 10 Sekoholestatrien-5Z, 7E, 10 (19) diol-1 a, 3 b.
RN-cholecalciferol; R-OH Oksidevit (oksiholekaltsiferol).
Synonyms: Alpha D 3, Van Alfa, Oksivitamin D 3, Oksidevit, Oksiholekaltsiferol, Etalfa, Alfa D 3, Etalfa, One-Alfa, Oxidevitum , Oxycholecalciferol.
The structure and action close to oksidevit cholecalciferol, t. E. Vitamin D 3.
Colourless crystals or white crystalline powder. Practically insoluble in water, easily soluble in alcohol; small and slowly dissolved in sunflower oil.
Oksidevit is a natural metabolite of vitamin DZ. Like other B vitamins D oksidevit regulates calcium and phosphorus metabolism, stimulates their absorption from the intestine and reabsorption in the kidney. It has a more pronounced antirahiticheskoy active than ergocalciferol.
Applied with rickets and rahitopodobnyh diseases requiring correction of calcium-phosphorus metabolism, osteogenesis imperfecta, osteoporosis and osteomalacia of various origins (including postmenopausal, steroid osteoporosis, etc.), As well as kidney disease associated with impaired metabolism of vitamin D, and mineral metabolism.
Apply oksidevit inside regardless of meal times.
Babies at prescribed diseases rahitopodobnyh 0.0005 - 0.003 mg per day depending on the age and the body weight for 2 - 3 months to 1 year.
In rickets apply to 0,001 mg a day every day for 10 days. Spend 3 courses with a 2-week break in between.
When bone disease (osteoporosis, osteomalacia) of various genesis dose is from 0.0005 to 0,003 mg per day for long periods (2 - 3 months to 1 year or more).
In chronic renal failure (CRF) children undergoing hemodialysis, with the aim of relief osteodystrophy appoint 0,001 mg per day with simultaneous application of ergocalciferol to 2000 IU daily for a long time. Adult patients with chronic renal failure on hemodialysis, designate 0,001 - 0,002 mg a day every day or every other day with subsequent dose reduction to 0.0005 mg depending on normalizing blood calcium and alkaline phosphatase activity.
The course of treatment, dlyashiysya 2 - 3 months, it is recommended to repeat 2 - 3 times a year.
When CRF requires the prior correction of hyperphosphatemia.
In renal transplant patients prophylactically appoint 0.00025 - 0.001 mg a day every day or every other day.
Oksidevitom Treatment should be under the permanent control of the content of calcium and phosphorus in the blood, as well as the activity of alkaline phosphatase (if CKD requires weekly monitoring).
Like vitamin D, oksidevit in doses exceeding the physiological need, can have toxic effects. Drug toxicity of vitamin D, but unlike him, does not accumulate in the body, and undergoes rapid catabolism and excretion, so when you stop the drug proceeds hypercalcemia usually resolves on its own.