Description medications: Fenilin (Phenylinum)
Fenilina (Phenylinum). Fenilindandion-2-one, 3.
Synonyms: Athrombon, Danilone, Dindevane, Diophindane , Emandione, Hedulin, Phenindionum, Phenylindandionum, Pindione, Thromasal, Thrombantin, Thrombophen, Trombosol, Thrombotyl and others.
White or creamy-white crystals. Very slightly soluble in water, slightly soluble in alcohol.
It refers to a group of indirect anticoagulants. According to the structure is different from the preparations of 4-oksikumarina, but the mechanism of action similar to them; causes hypoprothrombinemia associated with the violation of the formation of prothrombin in the liver, is also a decrease in the formation of Factor VII, IX, X
Blood clotting is slowed down only after the introduction of fenilina the body; in vitro anticoagulant this drug has no effect.
Lowering the concentration of clotting factors occurs in 8 - 10 hours and reaches a maximum after 24 - 30 hours after taking fenilina.
The cumulative effect is stronger than neodikumarina.
Indications for use are the same as for neodikumarina. Is the inside.
Generally administered in one day in a daily dose of 0.12 - 0.18 g of (3 - 4 divided doses) the 2nd day in a daily dose of 0.09 - 0.15 g, followed by 0.03 - 0 06 g per day depending on the blood levels of prothrombin.
Prothrombin index is maintained at 50 - 40%.
Higher doses for adults inside, off 0.05 g daily 0.2 g
For the prevention of thromboembolic complications appoint 1 - 2 times a day.
fenilinom Treatment is carried out under close medical supervision with the obligatory systematic study of blood prothrombin and other coagulation factors.
In acute thrombosis fenilin administered together with heparin.
Possible complications associated with the effect on the blood coagulation factors, aid measures for them and contraindications to the use fenilina are the same as for the 4-oksikumarina.
Fenilin may cause allergic reactions: dermatitis, fever, diarrhea, nausea, hepatitis, blood oppression.
In the treatment of some patients fenilinom notes palms staining orange and urine - in pink, which is associated with chemical transformations fenilina (transition to the enol form) and is not dangerous.
Method of issuance: powder and pills to 0.03 g
Storage: List A. Powder - in a well-closed container, protected from light; pills - in a dark place.