Description drugs: streptokinase (Streptokinase)
Streptokinase (Streptokinase) *.
The enzyme preparation derived from a culture -hemolytic b streptococcus group S.
Produced abroad under the title "Avelizin" (Awelysin) "[Company name drug AWD (Arzneimittelwerk Dresden GmbH, Germany)]," Streptaza "(Streptase)," Kabikinaza "(Kabikinase) [Previously issued domestic product streptoliaza excluded from the range].
Streptokinase has fibrinolytic activity due to its ability to interact with plasminogen blood. streptokinase with plasminogen complex possesses proteolytic activity and catalyzes the conversion of plasminogen to plasmin. Last capable of causing lysis of fibrin clots in the blood; inactivated fibrinogen, factors V and VII of blood coagulation.
Streptokinase activity is determined by the drug's ability to lyse a fibrin clot certain conditions, a mixture solution formed by fibrinogen and thrombin, and are expressed in international (International) units (IU or IU).
Apply streptokinase to restore patency of thrombosed blood vessels; drug induced lysis of blood clots, acting on them, not only from the surface but also penetrates into the thrombus (particularly when fresh thrombi).
Indications for use of streptokinase (avelizina and other drugs) are pulmonary embolism and its branches, thrombosis and embolism, peripheral arterial thrombosis of superficial and deep veins (legs, pelvis), acute myocardial infarction (during the first 12 hours), thrombosis of the retina eyes and other conditions that occur with acute thrombosis or embolism, and the threat of blood clots.
Enter streptokinase intravenously, and in necessary cases - intra.
Usually administered intravenously in an initial dose of 250 000 IU (IU) in 50 ml isotonic sodium chloride solution for 30 min (30 drops per minute). The dose is usually the beginning of a blood clot lysis. Streptokinase administration was then continued at a dose of 100,000 IU per hour. The total duration of administration is usually 16 - 18 hours subsequent treatment is carried out with heparin and indirect anticoagulants..
With extensive arterial and venous thrombosis sometimes need long-term administration of streptokinase.
Intraarterial streptokinase used in acute myocardial infarction (initial dose of 20 000 IU; maintenance - 2000 - 4000 IU per minute for 30 - 90 min).
In all cases, the introduction of streptokinase should be initiated as early as possible, as the best effect is observed in fresh thrombi.
streptokinase treatment is carried out under the control of the thrombin time and fibrinogen content of the blood.
When using streptokinase can develop non-specific reactions to the protein: headache, nausea, light fever, allergic reaction (corticosteroids is recommended when expressed allergic reactions).