Description of the medicine: Ambenum
Ambenum. [Ambene in the foreign literature is also called para-aminobenzoic acid, which has no antifibrinolytic activity (see Novokain).]. Para- (Aminomethyl) benzoic acid.
Synonyms: Pamba, Gumbix, Pamba, Styptopur.
White crystalline powder odorless. Poorly and slowly dissolves in water.
Antifibrinolytic agent. The structure and mechanism of action is close to the acid aminocaproic; Inhibits fibrinolysis by competitive inhibition of the plasminogen activating enzyme and inhibition of plasmin formation.
In comparison with the acid aminocapron is more active.
Applied for stopping bleeding during surgical interventions and various pathological conditions, accompanied by increased fibrinolytic activity of blood and tissues, as well as hemorrhagic diathesis of thrombocytopenic origin.
Introduce the drug intravenously struino in doses of 50-100 mg (5 - 10 ml of 1% solution). If necessary, introduce again at intervals of not less than 4 hours. The introduction of the amber can be combined with the infusion of a solution of glucose, giprolisates, anti-shock liquids.
In acute fibrinolysis, fibrinogen is also prescribed (see), controlling the fibrinolytic activity of the blood and the content of fibrinogen in it.
The maximum single dose of the drug is 100 mg (10 ml of 1% solution). The total daily dose and duration of treatment depend on the course of the disease.
Contraindications are the same as for aminocaproic acid.
Product: 1% solution in ampoules of 5 ml (50 mg).
Storage: in a place protected from light.
A gemostatic sponge with amben (Spongia haemostatica cum Ambeno), containing human blood plasma, ambene and calcium chloride, was developed. It is a dry, porous, hygroscopic substance of white color with a yellowish tinge. Apply topically to stop bleeding.