Lymphomas of the skin

Lymphomas of the skin A group of tumors developing primarily or predominantly in the skin of T- and B-lymphocytes. In this regard, distinguish between T-cell skin lymphomas (T-CLC) and B-cell skin lymphomas (B-CLC).

The clinical picture is characterized by diffuse infiltration of the dermis or the appearance of spots, plaques with unsharp borders, nodules, erythroderma.

Diagnosis is established based on histological examination.

Treatment. Depending on the form and stage of the disease, polychemotherapy (COP, MPA, etc.) is used, less often - monochemotherapy (small doses of chlorbutin) or radiation therapy, which in generalized forms should capture the entire surface of the body.

Sarcoma usually affects the skin of the limbs and trunk, less often the lymph nodes, visceral organs, bones. Can be combined with immunodeficiency states. The flow is slow. It is manifested by the development on the skin of multiple exophytic formations with a tendency to ulceration. Gradually such tumor nodules merge and form various sizes of ulcerous surfaces prone to infection. The underlying structures (soft tissues, bones) are also involved. The treatment uses a surgical method, radiation therapy, cytotoxic ointments. With far-reaching cases of the disease, chemotherapy is used (combination of dactinomycin, vincristine, adriamycin). Combinations that include prospidin, cyclophosphamide and some other drugs are also effective. Complete remission is achieved in 70% of cases, but relapse of the disease is not uncommon.