Tumors of the pancreas from the islets of Langergans
Tumors of the pancreas from the islets of Langergans. More often are adenomas (up to 90%). Characteristics of the tumor as malignant is based not on the data of the morphological study (tumor growths are highly differentiated), but on the occurrence of metastases, which are more often localized in the liver, sometimes in the lungs, bones, brain. 20% of tumors from islets are characterized by endocrine secretion, which largely determines the clinical picture of the disease. The size of the tumor is usually less than 2 cm, while the level of endocrine secretion from the size of the tumor does not depend. Thus, secreting adenomas can be diagnosed early. The tumors of the islets have different clinical characteristics depending on the cellular source of the tumor ((- or (-cells, other elements) .So, the tumor from the c-cells secrete glucagon and leads to hyperglycemia and dermatitis.The tumor from the (-cells (insuloma) secretes insulin And pridit to severe hypoglycemic crises.In other cases, gastritis is released and Zollinger-Ellison syndrome develops (sharp gastric hypersecretion, stomach ulcers, duodenum and jejunum), tumors that produce serotonin (carcinoid), lead to carcinoid syndrome. Cushing's.
The clinical course of tumors of islets is slow.
Surgical treatment (pancreas resection). However, in the presence of metastases, the operation is ineffective. Antitumor drugs give a good symptomatic effect in 30% of cases (5-fluorouracil - 500 mg IV and streptozotocin - 1000 mg IV, 1-5 days).
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