Premature sexual development
Premature sexual development - the onset of puberty in girls under 8 and in boys under 10 years.
Etiology, pathogenesis. In pathological processes in the pineal gland and hypothalamus in the hypothalamic-pituitary system, changes occur that resemble those in normal puberty and lead to an increase in the secretion of gonadotropic hormones in the pituitary gland, which in turn leads to sexual development that mimics the prepubertal and puberty periods (the so-called true Premature sexual development in both boys and girls, always isosexual). With gonadal tumors, tumors or dysfunction of the adrenal cortex, false premature sexual development occurs: the secretion of gonadotropins does not increase, and excessive production of sex hormones by the adrenal cortex or gonadal tumors does not correspond to changes characteristic of the normal prepubertal or pubertal period, the gonads remain infantile.
In girls, false premature sexual development can be heterosexual - with adrenogenital syndrome (see Women's diseases in the chapter "Obstetrics") or isosexual - in ovarian tumors, in boys - isosexual.
Symptoms. Acceleration of growth and increase in body weight, advancing peers in sexual development. In girls, an increase in the mammary glands, the appearance of pubic hair on the pubis, bloody discharge from the vagina, an increase in the uterus, appendages, respectively, in the prepubertal or pubertal period, in some cases regular menstruation appears. In boys - an increase in the external genitalia, the appearance of hair on the pubic and face, erection, pollutions. There is an increase in the vascular pattern, hyperpneumatization of the sinus of the underlying bone; The differentiation of the skeleton is accelerated. Early closure of the growth zones leads ultimately to short stature. Neurological symptoms can be detected: headache, fatigue, bulimia, polydipsia, symptoms of oculomotor nerve lesions.
Treatment. Oxyprogesterone coproplete, cyproterone acetate. Symptomatic therapy: neuroleptics, (melleril, etc.), tranquilizers (oxazepam, trioxazin, diazepam).
- Endocrine and metabolic diseases
- Acromegaly
- Viral Syndrome
- Congenital disorders of sexual differentiation
- Hyperinsulinism
- Hyperparathyroidism
- Hyperprolactinemia
- Hypogonadism (male)
- Hypoparathyroidism (tetany)
- Hypothyroidism (myxedema)
- Pituitary Nanism (dwarfism)
- Diabetes insipidus
- Diabetes sugar
- Discipuititarianism youthful
- Goiter diffuse toxic
- Goiter endemic
- Itenko-cushing's disease
- Interstitial-pituitary insufficiency
- Adrenal insufficiency
- Obesity
- Tumors
- Thyroiditis
- Pheochromocytoma
- Endocrine ophthalmopathy
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