ehsherihioza

Ehsherihioza - disease caused by various strains of enteropathogenic Escherichia coli. Proceeds with a primary lesion of the intestine. Source of infection are sick people and healthy bacillicarriers, the transmission mechanism of fecal-oral. Most children get sick.

Etiology, pathogenesis. Pathogen - Escherichia coli, which has a lot of antigenic variants. In children, the disease often causes 0 the following groups:. 011, 055, 026,086,0119, etc. In adults in most cases is the causative agent of Escherichia 0124. The introduction of the pathogen occurs in the small intestine. Endotoxin of Escherichia has enterotropnoe effect and causes a marked toxic damage of the intestinal mucosa. The general effect of the toxin is shown a fall in blood pressure, and sometimes the development of an infectious collapse.

Symptoms within. The incubation period is 3-6 days (usually 4-5 days). Ehsherihioza can proceed in the following clinical forms: 1) enteric disease of children; 2) The adult intestinal diseases; 3) sepsis. Children ehsherihioza intestinal forms occur in the form of varying severity of enteritis and enterocolitis in conjunction with the syndrome of general intoxication. In milder forms of the body temperature of low-grade, chair 3-5 times a day, liquid, sometimes a small amount of admixture of mucus. Moderate form begins acutely, there is vomiting, increased body temperature (38-39 ° C), bloating, stool up to 10 to 12 times per day, with mucus liquid. Severe forms are characterized by a pronounced toxicity, a chair up to 20 times per day, watery, frothy with mucus, sometimes streaked with blood. The body temperature rises to 39-40 "C, no appetite, the child is restless, pale skin, blood pressure is lowered: marked weight loss.

In adults, the disease caused by Escherichia 0124, resembles the flow and clinical symptoms of acute dysentery. It flows more frequently erased and light shapes, less frequently (15-20%) found moderate and severe (3%) form. Tenesmus and false desires are less common than with dysentery. Liquid Stool with mucus, in some patients with blood. On palpation, except spasm and soreness of the colon, marked enteritis symptoms - pain in the umbilical region, rough rumbling palpation cecum.

Differentiate ehsherihioza from dysentery and salmonella enterocolitis only on clinical grounds is difficult. Diagnosis is based on bacteriological examination of faeces.

Treatment. In milder forms ehsherihioza adults can restrict pathogenetic and symptomatic therapy. From etiotropic drugs used primarily aminoglycosides. Assign inside children monomitsin 10 000-25 000 IU / day (3-4 hour period of 6-8 hours), adults - 250 000 IU 4 times per day. Course of treatment 5-7 days. Use as neomycin (2.5 - 5 mg / kg per day for 6-8 days)., Kanamycin, etc. are used infusion therapy When expressed toxicosis.

Forecast of adults and children older than one year is favorable, the most severe disease occurs in infants in the first six months of life.

Preventive measures should be particularly stringent in all the medical institutions for children, where the children of the first year of life (especially the first half). Measures aimed at preventing the introduction of infection in these institutions, early detection and isolation of patients. For this purpose, examine on ehsherihioza pregnant women before delivery, as well as pregnant women, women in childbirth and newborns, who may be suspected esherihioznuyu infection. In identifying isolated cases, examined personnel carrier on pathogenic Escherichia. When ehsherihioza adult prophylaxis is carried out as well as in dysentery.