Stevens-Johnson syndrome
Stevens-Johnson syndrome - acute toxic-allergic disease, accompanied by generalized rashes on the skin and mucous membranes; Malignant variant of exudative erythema.
Symptoms, course. Suddenly, the body temperature rises, malaise, headache. Symmetrically there are sharply limited large pinkish or bright red spots on the skin, rarely - flattened edematous papules, often with a cyanotic periphery, in the center of some bubbles form. On the mucous membranes of the mouth, nose, eyes, larynx, genitals, in the area of the anus, there are blisters that are opened within 2-4 days; Formed bleeding erosion with scraps of tire blisters on the edge. The lips are swollen, covered with bloody crusts. The process can be complicated by hemorrhagic eruptions, epistaxis, purulent conjunctivitis, ulceration of the cornea. The resulting toxicosis can cause cardiovascular and pulmonary insufficiency, nephritis, etc.
The diagnosis is based on a characteristic beginning, a severe general condition, the presence on the skin of at least single eruptions typical for exudative erythema, the absence of acantholytic cells in the strokes, the negative symptom of Nikolsky.
Treatment. Corticosteroids, starting with 60 mg of prednisolone or 9 mg dexamethasone daily, plasmapheresis, haemodes for 100-150 ml every other day or the introduction of 30% sodium thiosulfate solution of 10-15 ml, calcium preparations. In the infectious-allergic nature of the disease, it is advisable to attach broad-spectrum antibiotics, salicylates; In the presence of hemorrhagic syndrome - vitamins P, K, ascorbic acid, calcium preparations. External apply 5% dermatol ointment; Rinsing with a 2% solution of boric acid, a solution of furacilin (1: 5000), in the presence of conjunctivitis, drops containing 1% hydrocortisone, sulfacyl sodium, etc. are used. As the process improves, the daily dose of corticosteroids is gradually reduced, the treatment is discontinued after clinical recovery.
The prognosis is good: the disease lasts 2-3 months. , Relapses are not observed.
- Skin and venereal diseases
- Actinomycosis of the skin
- Alopecia
- Angiitis (vasculitis) of the skin
- Atopic dermatitis (diffuse neurodermatitis)
- Balanoposthitis
- Warts
- Vitiligo
- Gonorrhea
- Dermatitis
- Ichthyosis
- Candidiasis
- Itching itch
- Condyloma spikelets
- Hives
- Lyell's syndrome
- Leprosy
- Lymphogranulomatosis of inguinal
- Leaven red flat
- Lichen otripeda
- Pink lichen
- Mastocytosis
- Microsporia
- Molluscum contagiosum
- Pyoderma
- Pocerucha (Prurigo)
- Psoriasis
- Prycchinot is true
- Skin cancer
- Rosacea
- Rubrophytia
- Seborrhea
- Syphilis
- Toxidermia
- Lupus
- Acne vulgaris (youthful)
- Favus (scab)
- Scabies
- Chancre soft
- Eczema
- Epidermophytia
- Erythema nodosum
- Erythrasm
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