| Start of section
Production, amateur Radio amateurs Aircraft model, rocket-model Useful, entertaining |
Stealth Master
Electronics Physics Technologies Inventions |
Secrets of the cosmos
Secrets of the Earth Secrets of the Ocean Tricks Map of section |
  |
| Use of the site materials is allowed subject to the link (for websites - hyperlinks) | |||
Navigation: => |
Home / Patent catalog / Catalog section / Back / |
|
INVENTION
Patent of the Russian Federation RU2286814
METHOD FOR TREATMENT OF SKIN CANCER AND MUCOSIUM SHELLS
The name of the inventor: Vazhenin Andrey Vladimirovich (RU); Voronin Mikhail Ivanovich (RU); Gyulov Khanakhmed Yarakhmedovich (RU); Kandakova Elena Y. (RU); Pelipenko Elena Anatolievna (RU); Kochetkova Svetlana Aleksandrovna (RU)
The name of the patent holder: Chelyabinsk Regional Oncology Center (RU)
Address for correspondence: 454087, Chelyabinsk, Gorkovskaya, 6, ap. 25, M.I. Voronin
Date of commencement of the patent: 2005.06.20
The invention relates to medicine, namely to oncology, and can be used to treat skin and mucosal cancer. A combined laser and radiation exposure is carried out by single-stage laser irradiation and a cancer dose of X-rays at a low-energy installation from a distance of 7-10 cm at a dose rate of 1 Gy / min to a maximal dose of 58-62 Gy for 0.4-3, 0 min. The laser action is carried out for 3 minutes with an average radiation power of 2.4 mW, a wavelength of 0.662 μm. The method prevents the occurrence and development of radiation damage to tissues and organs involved in the zone of radiation exposure.
DESCRIPTION OF THE INVENTION
The invention relates to medicine, namely to oncology, and can be used in close-focus radiation and low-intensity laser therapy of superficial malignant tumors of the skin and mucous membranes to prevent and treat damage resulting from radiation therapy.
Over the past decade (see Gusev, LI et al, Clinical Investigations of the Effectiveness of Low-Intensive Laser Radiation in Oncology, VNSTNIK NN Blokhin Russian Cancer Research Center RAMS, No. 2/2003, p. 36-41), the use of low-intensity Laser radiation (LLL) has taken a firm position as a highly effective way of treating and preventing many diseases and pathological conditions. Received and published data on the positive results of treatment LIL postoperative complications in cancer patients with different localizations, both in adults and in children. The efficacy of NLI in early radiation reactions of varying severity was proved. In addition, it was shown that laser radiation stimulates the body's reactivity in oncopathology.
Known in the art is a method for treating skin and mucosal cancers (see RU Patent No. 2088285, cl. A 61 N 5/06, filed 27.08.97), which includes joint alternating low-intensity laser radiation and after 6-25 Min - radiation exposure.
The disadvantage of the known method is the low reliability of the method, since While using it stimulates the reactivity of the organism in oncopathology, but taking into account the different capabilities of the organism of cancer patients of different ages and different degrees of neglect of the disease, the use of such a sequence does not allow the effect of a significant reduction in the frequency and depth of local radiation injuries and shortening of their treatment time.
In addition, only the tumor is exposed to the laser, without affecting the tissues and organs involved in the radiation exposure zone, which does not allow to achieve the effect of preventing the occurrence and treatment of radiation injuries.
The closest in terms of technical essence and achieved effect to the claimed method and selected as a prototype is a method for treating skin and mucosal cancer (see RU Patent No. 2111054, cl. A 61 N 5/067, filed 10.07.98, publ. 27.12.2000), which includes radiation irradiation followed by low-intensity laser radiation on tissues and organs involved in the radiation exposure zone. The laser action is carried out by radiation, predominantly red and infrared wavelengths of 0.63 and / or 0.89 microns in continuous or pulsed mode at a power of 0.3-25.0 mW and total energy collected per session of 0.1- 55.0 J, by remote and / or contact (and / or intraorganic and / or intravascular), in conjunction with gamma radiation.
The disadvantage of the known method, as well as in the analogue, is the low reliability of the method, because Exposure to laser radiation is carried out only 30-40 minutes after the end of radiation exposure, which does not contribute to the prevention of radiation damage, but is used primarily to treat adverse reactions that have occurred as a result of previous radiation exposure.
The object of the invention is to improve the reliability of the method by preventing the occurrence of radiation damage.
The technical result is the creation of an optimal method that allows to achieve the effect of preventing the occurrence of radiation complications of tissues and organs involved in the radiation irradiation zone by single-ray radiation exposure with low-intensity laser radiation.
The objective is achieved by the fact that in a known method for treating skin and mucosal cancer including combined radiation exposure with low-intensity laser radiation on tissues and organs involved in the radiation exposure zone, the combined laser and radiation effects are produced by simultaneous introduction to a tumor focus of a synchronous laser Irradiation and endocidal dose of X-rays at the installation from a distance of 7-10 cm with a dose rate of 1 Gy / min to max. 58-62 Gy for a period of 0.4-3.0 min, with one-stage laser exposure for 3 min With an average radiation power of 2.4 mW, a wavelength of 0.662 μm.
In addition, laser irradiation can overlap radiation exposure at the beginning and end of irradiation by 30-50 s, while one-stage laser-X-ray therapy can be performed daily for 15-20 days.
The conducted researches on the sources of patent and scientific and medical information showed that the proposed method is not known and does not follow explicitly from the material studied, i.e. Meets the criteria of "novelty" and "inventive level".
The proposed method can be used in the treatment of cancer patients, in particular close-focus radiation and low-intensity laser therapy of superficial malignant tumors of the skin and mucous membranes, with the possibility of preventing radiation complications, by using devices manufactured by domestic or foreign industry, therefore, the method meets the criterion "industrial applicability"
The simultaneous application of synchronous laser irradiation and a carcicidal dose of X-rays to the tumor combined laser and radiotherapy method allows not only completely to remove the tumor, but also to prevent or reduce the incidence of undesirable radiation reactions and complications.
Irradiation from a distance of 7-10 cm with a dose rate of 1 Gy / min to max doses of 58-62 Gy for 0.4-3.0 minutes, with a single-laser exposure for 3 min with an average radiation power of 2.4 mW, The wavelength of 0.662 μm avoids heavy radiation damage.
In addition, laser irradiation overlaps the radiation exposure at the beginning and end of the irradiation by 30-50 s, which allows not only to prevent radiation complications, but also to consolidate the achieved result, and carrying out one-stage laser therapy daily, for example, for 15-20 days, provides Only a complete cure for a malignant tumor, but also prevents possible radiation damage.
The method is performed on an improved close-focus X-ray therapy device RUM-21, equipped with a removable cylindrical nozzle in the form of a tube, with a through hole made in its side at an angle of 45-50 ° to the axis, with the possibility of placing a laser emitter (low-intensity laser light guide) in it.
On the surface of the patient's skin, a protective application is removed from leaded rubber or lead sheet and a hole is cut out according to the shape of the tumor, which should be 5 mm wider than the tumor. Depending on the shape and height of the patient's tumor, an additional detachable nozzle is taken to the rengenoterapevticheskoy tube. A light-guide of a low-intensity laser is introduced into the through-hole and the tumor is initially irradiated with a laser beam. After 0.3-0.5 minutes, an X-ray therapeutic device is connected and a combined laser and radiation exposure is made by simultaneous introduction of a synchronous laser exposure to the tumor focus with an average radiation power of 2.4 mW, a wavelength of 0.662 μm, and an endocidal dose of X- 10 cm with a dose rate of 1 Gy / min to max doses of 58-62 Gy for a period of 0.4-3.0 min. After disabling the X-ray irradiation after 0.3-0.5 min, laser irradiation is turned off, i.e. Laser irradiation overlaps the radiation effect at the beginning and end of irradiation for 30-50 s. Laserorentgenotherapy is carried out daily for 15-25 days.
Example 1
Ill Tipakov Ivan Elizarovych.
Diagnosis: "Basal cell carcinoma of the skin of the back of the nose."
Since September, a bleeding formation appeared on the skin of the back of the nose, which gradually increased in size. I went to the clinic of the OOD. Cytologically: basal cell carcinoma №1481. Since December 1, the course of close-focus X-ray therapy has been started on the advanced apparatus of the RUM-21, ROD 3.7 Gy daily. Irradiation time 40 s. The size of the focus is 0.7 × 0.6 cm. The filter is 0.5 mm. AI, S (the area of the outlet of the tube) = 2 cm2. Simultaneously, laser action was performed for 3 min through the hole of a cylindrical tube with a radiation power of 2.2 mW, with a wavelength of 0.662 μm.
At the end of the course of treatment, after the dose was administered to the primary tumor of SOD 55.5 Gy, complete clinical resorption was noted. Reactions from the skin during the entire course of treatment were absent. Directly with this method of treatment, the subjectively patient noted a feeling of warmth and light tingling in the area of contact of the device with the skin in the irradiation zone. There were no general reactions.
At observation times up to 4 months. The tumor did not recur.
Example 2
The patient Krivoshchapov Victor Stepanovich.
Diagnosis: "Skin cancer of the right cheek T1N0M0"
Over the past 2 years, notes the presence of education on the skin of the right cheek. I went to the clinic of the OOD. Histologically: squamous, non-coronary cancer №5997-99.
The irradiation was performed with an improved close-focus apparatus RUM-21, ROD 5.6 Gy daily. Irradiation time 1 min. 50 sec. The size of the focus is 0.8 × 0.6 cm. The filter is 1.2 mm. Al, S = 3 cm2 with one-step laser action for 3 min with an average radiation power of 2.4 mW, a wavelength of 0.662 μm.
By the end of the course of treatment, after the dose was administered to the primary tumor of 67 Gy, a marked regression of the tumor was noted. Reactions from the skin during the entire course of treatment were absent. Directly with this method of treatment, the subjective patient noted a feeling of warmth and light tingling in the area of contact of the tube with the skin. No general reactions were noted.
At follow-up of up to 3 months, no tumor growth was observed.
Example 3
Patient Shkurkin Valery Ivanovich. Diagnosis: Basal cell carcinoma of the forehead skin T1N0M0 "
Since his youth marks the presence of education on the skin of the forehead. During the year it began to bother - there was an itch. I went to the clinic of the OOD.
Diagnosis: "Basal cell carcinoma of the forehead skin T1N0M0"
Since his youth marks the presence of education on the skin of the forehead. During the year it began to bother - there was an itch. I went to the clinic of the OOD. Cytologically: Basaloma №989.
Since November 22, the course of X-ray therapy has been started on the improved close-focus apparatus RUM-21, ROD 3.7 Gy daily. The irradiation time is 40 s, the size of the focus is 1.2 × 1.4 cm. The filter is 0.5 mm, Al, S = 2 cm2, with one-stage laser action for 3 min with an average radiation power at the end of the fiber 2.2 mW, The wavelength of 0.662 μm.
At the end of the treatment course, after the dose was applied to the primary tumor of SOD 55.8 Gy, complete tumor regression was noted. Reactions from the skin during the entire course of treatment were absent. Directly with this method of treatment, the subjective patient noted a feeling of warmth and light tingling in the area of irradiation.
At observation times of up to 6 months. Tumor growth has not resumed.
One-stage synchronous radiotherapy and laser therapy was performed in 10 patients with basal squamous cell carcinoma of the skin. All patients achieved complete regression of the tumor and as an advantage, there was no radiation reactions of the skin.
Thus, in comparison with the prototype, simultaneous reduction of the cancerous dose of X-rays and synchronous laser irradiation to the tumor of the skin promotes an increase in the effectiveness of treatment (tumor cells decrease by 20% at the time of irradiation die faster) in the absence or significant decrease in the severity of radiation reactions and is safe for patients.
CLAIM
A method for the treatment of skin and mucosal cancers, comprising a combined radiation exposure with low-intensity laser radiation on tissues and organs involved in the radiation exposure zone, characterized in that a combined laser and radiation exposure is produced by simultaneous administration to the tumor focus of synchronous laser irradiation and a carcinocidal dose X-rays at a low-energy installation from a distance of 7-10 cm with a dose rate of 1 Gy / min to a max of 58-62 Gy for 0.4-3.0 min, while simultaneously performing a laser irradiation for 3 min with an average power Radiation 2.4 mW, a wavelength of 0.662 m.
A method of treating skin and mucosal cancers according to claim 1, characterized in that the laser irradiation overlaps the radiation exposure at the beginning and end of the irradiation for 30-50 seconds.
A method for treating skin and mucosal cancers according to claim 1, characterized in that a one-time laser-X-ray therapy is carried out daily for 15-20 days.
print version
Date of publication 25.08.11.2006гг
Comments
When commenting on, remember that the content and tone of your message can hurt the feelings of real people, show respect and tolerance to your interlocutors even if you do not share their opinion, your behavior in the conditions of freedom of expression and anonymity provided by the Internet, changes Not only virtual, but also the real world. All comments are hidden from the index, spam is controlled.