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INVENTION
Russian Federation Patent RU2189215

METHOD treatment of peptic ulcer of stomach and duodenum

METHOD treatment of peptic ulcer of stomach and duodenum

Name of the inventor: Minakov Eduard Vasilevich; Marina Romanova M.
The name of the patentee: Minakov Eduard Vasilevich; Marina Romanova M.
Address for correspondence: 394622, Voronezh, st. Student, 10, Voronezh State Medical Academy. Burdenko, patent department
Starting date of the patent: 1999.02.23

The invention relates to medicine, gastroenterology. The method includes pharmacological therapy H. pylori and holding transcutaneous magnetic laser therapy. The wavelength of 0.89 microns, a magnetic head 150 mT. Impact on the epigastric region, on the solar plexus, on the projection of the duodenum. Carried magnitolazeropunkturu 1.3 micron wavelength modulated mode, frequency 2.4 Hz, magnitoakupunkturnoy nozzle 50 mT. Exposure time of 10-30 with a biologically active point. Selecting the points of impact carried out depending on the state of autonomic balance. The method shortens treatment time, prolongs remission.

DESCRIPTION OF THE INVENTION

The invention relates to medicine, namely to gastroenterology and may be used in the treatment of gastric ulcer and duodenal ulcer.

A method of treating peptic ulcer (BU), which consists in the application of various schemes Helicobacter medication effective against the elimination of Helicobacter pylori (Hp) - up to 60-96%. The treatment regimens included the following groups of medications: colloidal bismuth subcitrate (De-nol), antibiotics (flemoksin, clarithromycin, and others), the preparations of the nitroimidazoles (Trichopolum, metronidazole, etc.), H 2 blockers (ranitidine, famotidine, etc. .), K-Na blockers ATPase (omeprazole et al.), which are used in various combinations (2, 3 or 4 drug), different courses (7 to 14 days), and the dosage varies drugs (Isakov B. A. Treatment of peptic ulcer associated with Hp achievements and unsolved problems // Clinical pharmacology and Therapeutics 1997 -... 1 - 12-17)..

However, H. pylori therapy has no effect on autonomic balance, indicators of electro-diagnostics by Nakatani, does not provide a 100% eradication of Helicobacter pylori, has no significant effect on the terms of relief of clinical symptoms, the timing of scarring, lengthening remission, reduction of recurrence. This therapy does not affect the general adaptive systems ulcer patient (in particular, in the autonomic balance), meanwhile, the state regulatory systems largely determines the rate of recurrence and prognosis of ulcer.

The technical result of the proposed method of treatment of gastric ulcer and duodenal ulcer - correction status of vegetative balance, indicators of electro-diagnostics by Nakatani through holding magnitolazernoj transcutaneous therapy and magnitolazeropunktury taking into account the individual characteristics of the status of vegetative balance and data clinico-endoskonicheskoy picture, and as a result - the acceleration of the relief of clinical symptoms, shortening of scarring, the achievement of the eradication of Helicobacter pylori, decrease gastric mucosal inflammation and duodenal ulcers (DU), the extension of remission, reduction of the frequency of relapses. This technical result is achieved by the fact that patients with peptic ulcer treatment is carried out, including in addition to drug therapy of H. pylori, carrying out 1 time per day during one session of the course 10-12 procedures transcutaneous magnetic laser therapy wavelength of 0.89 microns in length, 150 mT magnetic attachment, 2 min epigastric, at the solar plexus, on the projection of the duodenum, and for pain and / or ulceration size> = 0.6 cm with a frequency of 820 Hz down to 80 Hz; in the absence of pain and / or ulceration size <0.6 cm with a frequency of 360 Hz down to 80 Hz and in a modulated mode magnitolazeropunktury 1.3 micron wavelength of a frequency of 2.4 Hz magnitoakupunkturnoy nozzle 50 mT at 10-30 with a biologically active point, and at sympathicotonia - GI sedation points 4 points and toning E 25, E 36, MS 6; vagotonia toned with point 4 and GI sedating point E 25, E 36, MS 6; further - to the point of impact of the diagnosis according to Nakatani; when normotonii lazeropunkture carried out according to the diagnosis by Nakatani.

The proposed method is as follows.

To assess the autonomic balance in the patient duodenal ulcer on admission record cardiointervalogram for 5 minutes in the supine position and analyze the data taking into account the recommendations of the ESC / NASPE (Standards of Heart rate Variability. Circulation. Vol. 93. 5, March 1, 1996). In addition, patients underwent electroacupuncture diagnostics by Nakatani.

In appointing magnitolazeropunktury course take into account the following options:

1) if the patient has an initial sympathicotonia (RMSSD <15, LF / HF> 3,5), while the impact of reflexology points used sedation and toning GI 4 points E 25, E 36, MS 6;

2) if the patient in a vegetative status prevails vagotonia (RMSSD> 35, LF / HF <1), point magnitolazeropunkture toned GI 4, and sedating point E 25, E 36, MS 6;

3) In addition to these biologically active points (BAP) are used terms, the impact of which dictate the results of the diagnostics by Nakatani;

4) if the original vegetative balance maintained (normotoniya) magnitolazeropunkturu carried out according to the diagnosis by Nakatani.

Time of influence for one BAT: for sedation - 30, while toning - 10. In the course of 10-12 daily procedures.

In the appointment of transcutaneous magnetic laser therapy should be considered:

1) if the patient has severe pain and / or size of the ulcers according to esophagogastroduodenoscopy (EGD)> = 0.6 cm, transcutaneous magnetic laser exposure begin with a frequency of 820 Hz, followed by a gradual decrease in frequency as remitting clinical manifestations of disease to 80 Hz;

2) if there is no pain, and / or the size of ulcer defect does not exceed 0.6 cm, transcutaneous magnetic laser exposure begin with a frequency of 360 Hz down to 80 Hz.

Transcutaneous magnetic laser therapy is carried out by 2 minutes on epigastric area, on the solar plexus, on the projection of the duodenum. In the course of 10-12 daily procedures.

For trankutannoy therapy used LTA "Mustang-23" for laseropuncture LTA "Moth-reflex".

Example 1. Patient K., 32 years old, medical history ... 14.01.98 entered in the gastroenterological department of the Regional Clinical Hospital (EDO) complaining of intense pain in the epigastric region, nausea, general weakness.

Survey data:

- Antibodies to H +.

- Endoscopy: gastric mucosa (GM) brightly hyperemic, edematous, with erosions in the antrum, duodenum (KDP) hyperemia, on the front wall - ulcer 0.8 cm in diameter.

- Histological examination: the degree of Hp dissemination +++, the severity of the pathology of coolant (in points) - 38.

- Cytology: the degree of Hp dissemination +++.

- PH - meter: continuous activity of acid medium (pH in the range 1.8-2) atropinovy ​​test is weakly positive.

- Vegetative balance on mathematical analysis of heart rate (MARS): RMSSD = 10,23, LF / HF = 5,4, indicating a sympathic.

- Bioelectric balance (according to the diagnosis by Nakatani): IG-17, TR-7.

Diagnosis: duodenal ulcer (ulcer duodenal bulb, chronic gastritis type B, with erosions in the antrum), first identified, the aggravation.

The patient received a 7-day triple therapy and 1 times a day trankutannuyu magnetic laser therapy wavelength of 0.89 microns to 150 mT magnetic attachment with a pulse repetition rate of 820 Hz down to 80 Hz and magnitolazeropunkturu 1.3 microns wavelength in frequency modulated mode magnitoakupunkturnoy 2.4Hz nozzle 50 mT: IG sedation point 4 (30), toning (10) the points E 25, E 36, MS 6 (according to sympathicotonia MARS) for 10 days.

Survey data after treatment.

EGD (control): Coolant sluggish hyperemic, on the front wall of the duodenum - a gentle "scar."

Histological examination: the degree of contamination of Hp 0, SVP coolant = 28.

Cytology: the degree of contamination H 0.

Vegetative balance: RMSSD = 25,54, LH / HF = 2,1.

Bioelectrical balance: IG + 2, C + 3.

Complaints have disappeared on the 3rd day. The patient was discharged in satisfactory condition. Within a year of observation had no relapses.

Example 2. Patient B., 42, medical history ... 01/15/98 enrolled in gastroenterological department of OKB with complaints of mild epigastric pain, nausea, belching air. He considers himself sick for 5 years. Exacerbations 1 time in 2 years.

Survey data.

OBJECTIVE: normosthenic body type, language dryish, palpation mild soreness in the gastroduodenal area.

- Antibodies to H +.

- Endoscopy: Coolant hyperemic, edematous, with point erosions in the antrum, in the pyloric - ulcer 0.4 cm in diameter, duodenal bulb hyperemic.

- Histological examination: the degree of Hp dissemination ++ SVP coolant (in points) = 32.

- Cytology: the degree of Hp dissemination ++.

- PH - meter: continuous activity of acid medium (pH in the range 1.7-1.9), atropinovy ​​test positive.

- Vegetative balance (on Mars): RMSSD = 23,4, LF / HF = 2,6, that cvidetelstvovalo of normotonii.

- Bioelectric balance: P-20 MS + 11, the R-6, the GI + 16.

Diagnosis: gastric ulcer (pyloric ulcer, chronic gastritis type B, with erosions in the antrum), mild course, exacerbation.

The patient received a 7-day triple therapy and 1 times a day trankutannuyu magnetic laser therapy wavelength of 0.89 microns to 150 mT magnetic attachment with a pulse repetition rate of 360 Hz down to 80 Hz and magnitolazeropunkturu 1.3 microns wavelength in frequency modulated mode 2.4 Hz magnitoakupunkturnoy nozzle 50 mT: toning P9 GI sedation 6 (according to the data of the diagnosis according to Nakatani abuse lo-channel P-GI) for 10 days. Survey data after treatment:

EGD (control): the coolant and duodenum slightly hyperemic, in pyloric - "star-shaped" scar.

Histological examination: the degree of contamination of Hp 0, SVP-21 coolant.

Cytology: the degree of contamination H 0.

Vegetative balance (according to MARS): RMSSD = 26,78, LH / HF = 2,3.

Bioelectrical balance: MS + 3, P-2.

The patient was discharged in satisfactory condition with recommendations. Relapses during the observation period were absent.

Example 3. Patient G., 33 years old, medical history ... did 02.02.98, in the gastroenterological department of OKB with complaints of pain in the epigastric region in 1-1,5 hours after eating, nausea, vomiting. Ill for 4 years. Exacerbations 1-2 times a year.

Survey data:

- "Antibodies to H +.

- "EGD: Coolant brightly hyperemic, edematous, with erosions in the antrum and pylorus, duodenum bulb hyperemic, deformed scar on the front and rear walls - two" kissing "ulcers, 0.7 and 0.4 cm in diameter (respectively).

- Histological examination: the degree of Hp dissemination +++, SVP of coolant (in points) = 41.

- Cytology: the degree of Hp dissemination +++.

- PH - meter: increased activity of acid, atropinovy ​​test is negative, the predominance of humoral component in the genesis of gastric acid.

- Vegetative balance MARS: RMSSD = 54,36, LF / HF = 0,8, indicating a parasimpatikotonii.

- Bioelectric balance: IG-20 + E 85, TR-32, RP-17, R + 60, V-29.

Diagnosis: duodenal ulcer (duodenal bulb multiple ulcers, chronic gastritis type B, with erosions, duodenal bulb scar deformation), for moderate severity, exacerbation.

The patient received a 7-day triple therapy and 1 times a day trankutannuyu magnetic laser therapy wavelength of 0.89 microns to 150 mT magnetic attachment with a pulse repetition rate of 820 Hz down to 80 Hz and magnitolazeropunkturu 1.3 microns wavelength in frequency modulated mode 2.4 Hz magnitoakupunkturnoy nozzle 50 mT: toning point GI 4, sedation points E 25, E 36, the MS 6 (according to the MARS); toning RP 3 E 40 sedation, sedation R 4, toning V 64 (according abuse lo-channel diagnostic data for Nakatani RP-E, RV) for 12 days.

Survey data after treatment

EGD (control): the coolant and the KDP sluggish hyperemic, onion KDP deformirova scar on the front and back walls of the KDP - fresh scars.

Histological examination: the degree of contamination of Hp 0, SVP coolant = 27.

Cytology: the degree of contamination H 0.

Vegetative balance (according to MARS): RMSSD = 29,67, LH / HF = 1,78.

Bioelectrical balance: R + 11, E + 22, TR-8.

Clinical pryavleniya cropped on the 4th day. Within a year of observation had no relapses.

Example 4 Patient N., 34 years, medical history ... 16.11.98 entered in the gastroenterological department of OKB with complaints of mild epigastric pain, nausea, general weakness.

Survey data:

- Antibodies to H +.

- Endoscopy: Coolant brightly hyperemic, edematous, with erosions in the antrum, duodenal bulb hyperemic, on the front wall - ulcer 1.0 cm in diameter.

- Histological examination: the degree of Hp dissemination +++, SVP of coolant (in points) = 37.

- Cytology: the degree of Hp dissemination +++.

- PH - meter: continuous activity of acid medium (pH in the range 1.8-2) atropinovy ​​test positive.

- Vegetative balance RMSSD = 12,44, LF / HF = 5,1, indicating a sympathic.

- Bioelectric balance: E + 12, IG-7, RP-24.

Diagnosis: duodenal ulcer (ulcer duodenal bulb, chronic gastritis type B, with erosions in the antrum), first identified, the aggravation.

7-day triple therapy in patients with H. pylori has been appointed. However, on the third day, she developed an allergic reaction in the form of urticaria, and therefore the antibiotic metronidazole flemoksin and were canceled. The patient continued to receive Denol trankutannuyu and magnetic laser therapy wavelength of 0.89 microns, a magnetic nozzle 150 mT with a pulse repetition rate of 820 Hz down to 80 Hz and magnitolazeropunkturu 1.3 micron wavelength modulated at a frequency of 2.4 Hz mode magnitoakupunkturnoy nozzle 50 mT: IG sedation point 4 (30), toning point E 25, E 36, the MS 6 (according to the data of the MARS sympathicotonia); e sedation 42, toning RP 4 (according to Nakatani) within 10 days. At follow-up examination in this patient data endoscopy, terms of scarring, Cropped clinical symptoms, changes in coolant SVP had no significant differences from the main group of patients; the degree of contamination (according to the cytological and histological examination) = 0.

Consequently, this method of treatment is effective in reducing the duration of the course of treatment with antibacterial agents and can be used, including, in the category of patients with allergic history.

Application of the method of treatment of gastric ulcer and duodenal ulcer leads to a correction of the autonomic balance, reduce the severity of the pathology of the gastroduodenal mucosa, accelerates the relief of clinical symptoms, reduces the duration of scarring, prolongs remission, reduce the frequency of relapses.

CLAIM

1. A method for the treatment of gastric ulcer and duodenal ulcers, including pharmacological therapy H. pylori, characterized in that the further, taking into account the individual characteristics of the state of autonomic balance, clinical and endoscopic data, perform consistent application of transcutaneous magnetic laser therapy wavelength of 0.89 microns in length, the magnetic attachment 150 mT 2 min epigastric region, of the solar plexus, the projection on the duodenum, and for pain and / or ulceration amount equal to or greater than 0.6 cm, with a 820 Hz frequent down to 80 Hz; in the absence of pain and / or ulceration size less than 0.6 cm with a frequency of 360 Hz down to 80 Hz and in a modulated mode magnitolazeropunktury 1.3 micron wavelength of a frequency of 2.4 Hz magnitoakupunkturnoy nozzle 50 mT at 10-30 with a biologically active point, and when carried out sympathicotonia sedatirovanie point GI 4 and toning points E 25, E 36, MS 6; vagotonia tone at point 4 and GI sedating point E 25, E 36, MS 6; when normotonii magnitolazeropunkturu carried out according to the diagnosis by Nakatani.

2. The method of claim. 1, characterized in that it further affect the diagnostic point according to Nakatani.

print version
Publication date 29.03.2007gg